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LTA — NOS2

Text-mined interactions from Literome

Kuo et al., J Biomed Sci 2003 : A phosphatidylcholine-phospholipase C ( PC-PLC ) inhibitor ( D-609 ) and a phosphatidylinositol-phospholipase C ( PI-PLC ) inhibitor ( U-73122 ) attenuated LTA induced iNOS expression and NO release ... Two PKC inhibitors ( Go 6976 and Ro 31-8220 ), an NF-kappaB inhibitor ( pyrrolidine dithiocarbamate ; PDTC ), and long-term ( 24 h ) 12-phorbol-13-myristate acetate ( PMA ) treatment each also inhibited LTA induced iNOS expression and NO release
Auguet et al., FEBS Lett 1992 : We provide evidence that lipoteichoic acid (LTA) from Staphylococcus aureus, a micro-organism without endotoxin, also induces nitric oxide synthase
Hsiao et al., Biochem Pharmacol 2004 (Shock, Septic) : We also compared the relative inhibitory activities and mechanisms of PMC, a novel potent antioxidant of alpha-tocopherol derivatives, with those of YC-1, an sGC activator, on the induction of iNOS expression by LTA in cultured macrophages in vitro and LTA induced hypotension in vivo
Chien et al., Neuroscience 2005 : We report here that LTA derived from gram positive bacteria ( Staphylococcus aureus ) significantly induces NO release and iNOS expression in primary microglia
Kao et al., Immunology 2005 : In this study, we further investigated the roles of tyrosine kinase, phosphatidylinositiol 3-kinase (PI3K)/Akt, and p38 mitogen activated protein kinase ( MAPK ) in LTA induced iNOS expression and NO release in RAW 264.7 macrophages ... Tyrosine kinase inhibitors ( genistein and tyrphostin AG126 ), PI3K inhibitors ( wortmannin and LY 294002 ), and a p38 MAPK inhibitor ( SB 203580 ) attenuated LTA induced iNOS expression and NO release in concentration dependent manners
He et al., Mol Immunol 2006 : RT-PCR analysis demonstrated that LPS, LTA , and CpG-ODN induced inducible nitric oxide synthase (iNOS) expression in monocytes ; whereas the other agonists did not
Jiang-Shieh et al., J Neurosci Res 2005 : In response to LTA , isolated microglia increased the expression of inducible nitric oxide synthase and major histocompatibility complex class II antigen
Chang et al., Cell Signal 2006 (MAP Kinase Signaling System) : This study was carried out to further investigate the roles of COX-2 and prostaglandin E2 ( PGE2 ) in LTA induced iNOS expression and NO release in RAW 264.7 macrophages ... We recently reported that lipoteichoic acid (LTA) , a cell wall component of the gram positive bacterium Staphylococcus aureus, stimulated inducible nitric oxide synthase (iNOS) expression, nitric oxide ( NO ) release, and cyclooxygenase-2 (COX-2) expression in RAW 264.7 macrophages ... LTA induced iNOS expression and NO release were inhibited by a non-selective COX inhibitor ( indomethacin ), a selective COX-2 inhibitor ( NS-398 ), an adenylyl cyclase ( AC ) inhibitor ( dideoxyadenosine, DDA ), and a protein kinase A (PKA) inhibitor ( KT-5720 ) ... These results suggest that LTA induced iNOS expression and NO release involve COX-2 generated PGE2 production, and AC, PKA, p38 MAPK, and NF-kappaB activation in RAW 264.7 macrophages
Huang et al., Int Immunopharmacol 2007 : In the present study, we found that Nor-wogonin ( N-Wog ; 5,7,8-trihydroxyl flavone ), a structural analogue of Wog with an OH substitution at C8, performed different effect on LPS- or lipoteichoic acid (LTA) induced iNOS gene expression and nitric oxide ( NO ) production in macrophages
Lin et al., Chem Biol Interact 2009 : Transfection of a dominant negative JNK plasmid inhibited LPS- and LTA induced iNOS/NO production and JNK protein phosphorylation, suggesting that JNK activation is involved in LPS- and LTA induced iNOS/NO production ... CoPP effectively suppressing LPS- and LTA induced iNOS/NO production through blocking JNK activation and iNOS enzyme activity via a HO-1 independent manner is first demonstrated herein
Chiu et al., Chem Biol Interact 2009 : This study was further aimed to evaluate the effects of propofol on LTA induced iNOS gene expression in macrophages and its possible molecular mechanisms ... Co-treatment with propofol and TLR2 siRNA synergistically ameliorated LTA induced iNOS mRNA expression and nitrite production
Chien et al., Shock 2012 : Reductions of LPS-, LTA-, and PGN induced phosphorylated c-Jun N-terminal kinase, c-Jun protein, and activator protein 1 luciferase activity by J2, d, and 15d were identified, and the addition of the HO-1 inhibitor, tin protoporphyrin, reversed the inhibitory effects of d and 15d on LPS- and LTA induced iNOS/NO , phosphorylated c-Jun N-terminal kinase, and c-Jun protein expressions by macrophages
Huang et al., Toxicol Appl Pharmacol 2013 (Inflammation) : LTA induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein levels increase in a concentration- and time dependent manner ... Administration of TLR2 antagonist effectively inhibited LTA induced NO, iNOS , and COX-2 expression ... We also found that LTA induced iNOS and COX-2 up-regulation were attenuated by p38, JNK, and PI3-kinase inhibitors ... Treatment of cells with NF-?B and AP-1 inhibitors antagonized LTA induced iNOS and COX-2 expression ... HO-1 activator CoPP IX dramatically reversed LTA induced iNOS expression
Park et al., Int Immunopharmacol 2013 : In microglia, schizandrin C significantly inhibited lipoteichoic acid (LTA) stimulated pro-inflammatory cytokines and chemokines, prostaglandin E2 ( PGE2 ), nitric oxide ( NO ), and reactive oxygen species ( ROS ) production, and inducible nitric oxide synthase (iNOS) , cyclooxygenase-2 (COX-2), and matrix metallopeptidase-9 (MMP-9) protein expressions
De Kimpe et al., Br J Pharmacol 1995 (Acute Kidney Injury...) : 4. The induction of nitric oxide synthase activity in lungs by LTA was attenuated by WEB2086 from 98 +/- 17 to 40 +/- 15 pmol L-citrulline 30 min-1 mg-1 protein ( P < 0.01 ), but not by BN52021 ( 148 +/- 21 pmol L-citrulline 30 min-1 mg-1 protein )
Hattor et al., Biochem Biophys Res Commun 1997 : Lipoteichoic acid (LTA) , a wall fragment of gram positive bacteria, induces an isoform of NO synthase (iNOS) in vascular smooth muscle cells and macrophages which produces large quantities of NO and profound vasodilation in rats ; this process may be involved in the cause of gram positive septic shock ... This study investigates the effect of LTA from Staphylococcus aureus on NO synthesis and iNOS mRNA induction in a mouse macrophage cell line ( J774 ) ... The induction of NO synthesis and iNOS gene expression in response to LTA was significantly inhibited by an anti-mouse CD14 monoclonal antibody
Hattori et al., J Vasc Res 1998 : LTA induces the gene expression of iNOS and GTP cyclohydrolase I (GTPCH) as well as the formation of NO and tetrahydrobiopterin ( BH4 ), effects which are synergistic with interferon-gamma