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Zhang et al., J Neurochem 1999
(Glioma...) :
Inhibition of p38 MAPK had no significant effect on opioid induced ERK activation, indicating that
p38 MAPK activity was not
required for
ERK activation, though its stimulation preceded ERK activation
Zimmermann et al., J Biol Chem 2001
(MAP Kinase Signaling System) :
Proteasome- and
p38 dependent regulation of
ERK3 expression
Park et al., J Biol Chem 2001
(Reperfusion Injury) :
In summary, post-ischemic JNK and
p38 ( but not
ERK1/2 )
activation was markedly reduced in a model of kidney ischemic preconditioning that was established in the mouse
Page et al., Am J Physiol Lung Cell Mol Physiol 2001
:
Chemical inhibitors of
p38 induced modest
ERK phosphorylation and activation
Maulon et al., Oncogene 2001
(MAP Kinase Signaling System) :
We show that thrombin mediated ERKs activation requires both PTK and PKC activities, whereas
p38 MAPK activation is
dependent only on PTKs. Thrombin induced
ERK and p38 MAPK activation was more pronounced in p56Lck deficient cells indicating that this PTK exerts a negative control on MAPK activity
Barouch et al., J Leukoc Biol 2001
(MAP Kinase Signaling System) :
NGF
induced phosphorylation and activation of extracellular signal regulated kinase,
Erk1/Erk2 and c-Jun amino-terminal kinase, whereas it did not induce phosphorylation of
p38 mitogen activated protein kinase
Sheth et al., Surgery 2001
(MAP Kinase Signaling System) :
These data show that
p38 inhibition
enhances ERK activity during endotoxemia
Kushida et al., Am J Physiol Cell Physiol 2001
(MAP Kinase Signaling System) :
Activation of
p38 was weak compared with that of JNK, and
ERK was not
activated at all
Park et al., Hepatology 2002
(Carcinoma, Hepatocellular...) :
However, inhibition of the JNK pathway suppressed
p38 but
induced transient
ERK activation
Bolla et al., J Vasc Res 2002
:
This contraction requires
p38 MAPK activation, but did not
involve ERK1/2 MAPK activation although both were activated
Kim et al., J Korean Med Sci 2002
(MAP Kinase Signaling System) :
It inhibited
ERK phosphorylation, but did not
inhibit p38 phosphorylation
Rumora et al., Biochem Biophys Res Commun 2003
(MAP Kinase Signaling System) :
A specific
p38 inhibitor SB 203580 also
stimulated ERK activation and cell survival
Niles et al., Cancer Lett 2003
(MAP Kinase Signaling System...) :
Although resveratrol did not alter the phosphorylation of
p38 or JNK MAP kinases in either cell line, it
induced phosphorylation of
ERK1/2 in A375, but not in SK-mel28 cells
Burlando et al., Cell Physiol Biochem 2003
(Carcinoma, Hepatocellular) :
Cell pre-incubation with p38 inhibitors indicated that
ERK activation by H ( 2 ) O ( 2 ) is
prevented by concomitant activation of
p38
Mukhopadhyay et al., J Biol Chem 2004
(Carcinoma, Squamous Cell...) :
Interestingly blocking
p38 MAPK activity
enhanced ERK1/2 phosphorylation, suggesting reciprocal regulation between the ERK1/2 and p38 MAPK pathways
Zauli et al., Blood 2004
(Bone Resorption) :
Of note, the addition of TRAIL to RANKL plus M-CSF did not affect
ERK1/2 but it profoundly
inhibited p38/MAPK phosphorylation
Pan et al., J Cell Physiol 2005
(Cardiomegaly) :
The phosphorylation of
ERK and JNK
induced by overexpression of WT PKCalpha, and the phosphorylation of
p38 induced by WT PKCdelta, were regulated by Rho GTPases
Choi et al., Biochem Biophys Res Commun 2004
:
A specific inhibitor of JNK, SP600125, abolished paclitaxel induced HO-1 mRNA expression, whereas PD98059, a specific inhibitor of
ERK , and SB203580, a specific
inhibitor of
p38 , had no significant effect
Han et al., Cell Tissue Res 2004
:
These alterations in protein level of adhesion molecules and in the phosphorylation of mitogen activated protein kinases by glucose were blocked by inhibition of PKC or
p38 but were synergistically
increased by the inhibition of
ERK
Baines et al., J Mol Cell Cardiol 2005
:
While a fair amount of discordance exists in the literature, we will weigh evidence that largely suggests a pro-apoptotic regulatory
role for the
p38 mitogen activated protein kinase, JNK, and PKCdelta, yet an anti-apoptotic regulatory role for
ERK , PKCepsilon, JAK, and calcineurin in the myocardium
Shih et al., Food Chem Toxicol 2005
(Adenocarcinoma...) :
In addition, the malvidin treatment significantly increased the p38 kinase expression and
inhibited the
ERK activity, and the effects of malvidin on caspase-3 activation were blocked, respectively, by the ERK and
p38 inhibitors
Yeh et al., Carcinogenesis 2005
(Carcinoma, Hepatocellular...) :
SB203580, a specific inhibitor of
p38 and PD98059, a specific
inhibitor of
ERK , abolished sulforaphane induced MT protein expression, whereas SP600125, a specific inhibitor of JNK, had no significant effect
Han et al., FEBS Lett 2005
:
While extracellular signal regulated kinase ( ERK ) and
p38 activation was detected in Prx II ( -/- ) MEF,
ERK and c-Jun N-terminal kinase (JNK) activation was
detected in Prx II ( -/- ) skin
Wang et al., Blood 2006
(MAP Kinase Signaling System...) :
Thus, our results suggested that tumor induced
p38 MAPK activation and
ERK inhibition in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer
Oh et al., Exp Cell Res 2006
:
Basal
ERK phosphorylation was elevated and basal
p38 kinase phosphorylation was
reduced in paclitaxel non treated TB4-HeLa cells
Guest et al., Antioxid Redox Signal 2006
(Mechanotransduction, Cellular) :
In conclusion, redox-sensitive activation of
ERK1/2 ( MAPK ) and redox-insensitive
activation of
p38 ( MAPK ) regulate straininduced MCP-1 expression in RASM cells
Kook et al., Mol Cells 2008
(Mechanotransduction, Cellular) :
Partial inhibition of
p38 phosphorylation
increased cellular levels of MyoD and
p-ERK in stretched C2C12 cells, along with increased myotube formation ... These results suggest that cyclic stretch inhibits the myogenic differentiation of C2C12 cells by activating
p38 mediated signaling and
inhibiting ERK phosphorylation
Browne et al., Biochem Biophys Res Commun 2008
:
ERK5 activation by either TGF-beta or epidermal growth factor (EGF) was also
inhibited by the
p38 MAP kinase inhibitor, SB-202190
Utsugi et al., J Immunol 2009
(MAP Kinase Signaling System) :
PI3K p110beta siRNA inhibited JNK activation, but not
p38 MAPK or
ERK activation , stimulated by LPS, while PI3K p110alpha siRNA did not affect LPS induced JNK, p38 MAPK, or ERK activation in both cell types
Imai et al., J Periodontol 2009
(Halitosis...) :
The activation of
ERK1/2 and p38 induced by H2S was
inhibited by the specific inhibitor of MAPK/ERK kinase ( [ MEK ] ; U0126 ) or
p38 ( SB203580 )
Su et al., Anesth Analg 2012
(Disease Models, Animal...) :
The response of the pial artery to hypotension and hypercapnia was monitored in piglets equipped with a closed cranial window before and after hypoxia and ischemia in the presence or absence of U0126, an inhibitor for the protein kinase upstream of
ERK , sp600125, an inhibitor of c-Jun-N-terminal kinase or sb203580, an
inhibitor of
p38
Qi et al., Front Biosci (Elite Ed) 2012
(Reperfusion Injury) :
Moreover, the phosphorylation of AKT and
ERK1/2 in the liver was
enhanced , while the phosphorylation of JNK,
p38 and p65 was suppressed
Hu et al., J Biol Chem 2012
(Inflammation) :
p38a deficiency also inhibits the activation of Akt but
enhances the activation of
ERK in response to T cell receptor engagement without impacting IL-2/Stat5 signaling
Gutstein et al., Anesthesiology 1997
:
Transient experiments in COS cells revealed potent stimulation of
ERK by mu and delta receptor activation, weak stimulation of stress activated protein kinase by all receptor types, and no
activation of
p38
Ludwig et al., J Biol Chem 1998
:
ERK activation is strongly
enhanced by overexpression of
p38 and mitogen activated protein kinase kinase 6 ( MKK6 ) but is blocked by dominant negative kinase versions of p38 and MKK6 or the specific p38 inhibitor SB203580
Alexandrov et al., Mol Pharmacol 1998
:
Anisomycin caused
p38 activation and
ERK inhibition quantitatively similar to those produced by phenylephrine
Ravanti et al., J Biol Chem 1999
:
These results show that collagen dependent induction of MMP-13 in dermal fibroblasts requires
p38 activity, and is
inhibited by activation of
ERK1,2