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MAPK8 — TRAF3
Pathways - manually collected, often from reviews:
-
NCI Pathway Database CD40/CD40L signaling:
JNK family-active (MAPK8/MAPK9/MAPK10)
→
CD40/CD40L (trimer)/TRAF3 (trimer) complex (CD40LG-CD40-TRAF3)
(modification, collaborate)
Xie et al., J Exp Med 2004
Evidence: mutant phenotype, assay
Text-mined interactions from Literome
Basaki et al., Arch Biochem Biophys 2002
(Burkitt Lymphoma) :
We report here that CD40 induced
TRAF3 dependent activation of
mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase ( ERK ) kinase 1 ( MEK1 ) is involved in the upregulation of IL-4-driven germline C epsilon transcription in a human Burkitt 's lymphoma B cell line, DG75
Horie et al., Microbes Infect 2007
(HIV Infections) :
TRAF activation of C/EBPbeta ( NF-IL6 ) via p38
MAPK induces HIV-1 gene expression in monocytes/macrophages
Funakoshi-Tago et al., Cytokine 2009
:
On the other hand,
TRAF6 deficiency did not
affect the TNFalpha induced activation of
mitogen activated protein ( MAP ) kinases , ERK, JNK, and p38