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EPHB2 — MAP3K8

Text-mined interactions from Literome

Kikuchi et al., J Dent Res 2003 : These findings indicate that Cot/Tpl2 is essential for LPS induced ERK activation and RANKL induction in osteoblasts
Robinson et al., Mol Cell Biol 2007 : LPS activation of ERK requires TPL-2 release from associated NF-kappaB1 p105, which blocks TPL-2 access to its substrate, the ERK kinase MEK ... Here we demonstrate that TPL-2 activity is also regulated independently of p105, since LPS stimulation was still needed for TPL-2 dependent activation of ERK in Nfkb1 ( -/- ) macrophages ... Mutation of this conserved residue to alanine ( A ) blocked the ability of retrovirally expressed TPL-2 to induce the activation of ERK in LPS stimulated Nfkb1 ( -/- ) macrophages
Hall et al., J Biol Chem 2007 (Arthritis, Rheumatoid...) : We have developed a series of highly selective and potent Tpl2 inhibitors, and in the present study we have used these inhibitors to demonstrate that the catalytic activity of Tpl2 is required for the LPS induced activation of MEK and ERK in primary human monocytes
Rousseau et al., J Cell Sci 2008 (MAP Kinase Signaling System) : TPL2 mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS stimulated macrophages
Zacharioudaki et al., J Immunol 2009 : Activation of ERK1/2 via Tpl2 appeared necessary for the induction of IRAK-M because gAd did not induce IRAK-M in Tpl2 ( -/- ) macrophages or in macrophages pretreated with the MEK1/2 inhibitor UO126
Johannessen et al., Nature 2010 (MAP Kinase Signaling System...) : COT activates ERK primarily through MEK dependent mechanisms that do not require RAF signalling
Hebron et al., Br J Haematol 2013 (Multiple Myeloma...) : In myeloma tumour cells, MAP3K8 acts as mitogen induced MAP3K in mitosis and is required for TNFa mediated ERK activation
Martel et al., PloS one 2013 : The Protein Kinase TPL2 Is Essential for ERK1/ERK2 Activation and Cytokine Gene Expression in Airway Epithelial Cells Exposed to Pathogen Associated Molecular Patterns ( PAMPs ) ... Inhibition of TPL2 activity with a pharmacological inhibitor ( Compound 1 ) not only prevented ERK1/ERK2 activation but also decreased cytokine synthesis in response to pathogen associated molecular patterns