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EPHB2 — PSAP

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Hiraiwa et al., Glia 1999 : Recently, we demonstrated that prosaposin and prosaptides ( peptides encompassing the neurotrophic sequence in prosaposin ) prevent cell death and increase extracellular regulated kinase (ERK) phosphorylation and sulfatide content in primary Schwann cells or oligodendrocytes ( Hiraiwa et al., 1997a )
Misasi et al., FASEB J 2001 (Adrenal Gland Neoplasms...) : Prosaposin treatment induced pheochromocytoma cells ( PC12 ) to enter the S phase of the cell cycle ; this effect was inhibited by the MEK inhibitor PD98059, indicating that prosaposin induced ERK phosphorylation is required for stimulation of DNA synthesis