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EPHB2 — STIP1

Text-mined interactions from Literome

Americo et al., Biochem Biophys Res Commun 2007 (Glioblastoma) : Both hyperosmolarity induced by sucrose and monodansyl-cadaverine blocked Erk activity induced by hop/STI-1 , without affecting the high basal Akt activity typical of A172
Caetano et al., J Neurosci 2008 (MAP Kinase Signaling System) : The secreted cochaperone STI1 triggers activation of protein kinase A (PKA) and ERK1/2 signaling by interacting with the cellular prion ( PrP ( C ) ) at the cell surface, resulting in neuroprotection and increased neuritogenesis ... In contrast, a PrP ( C ) mutant lacking endocytic activity was unable to promote ERK1/2 activation induced by STI1 , whereas it reconstituted PKA activity in the same condition, suggesting a key role of endocytosis in the former process ... The activation of ERK1/2 by STI1 was transient and appeared to depend on the interaction of the two proteins at the cell surface or shortly after internalization ... These results show that PrP ( C ) endocytosis is a necessary step to modulate STI1 dependent ERK1/2 signaling involved in neuritogenesis
Wang et al., Mol Cell Proteomics 2010 (Ovarian Neoplasms) : Functionally, recombinant STIP1 significantly induced ERK phosphorylation, promoted DNA synthesis, and increased Ki-67 immunoreactivity in ovarian cancer cells, suggesting that STIP1 in vitro promotes cell proliferation