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FGF2 — PTGS2

Text-mined interactions from Literome

Kawaguchi et al., J Bone Miner Res 2000 (Bone Resorption) : COX-2 was highly expressed and its messenger RNA ( mRNA ) level was stimulated by FGF-2 in osteoblastic cells whereas it was undetectable or not stimulated by FGF-2 in cells of osteoclast lineage
Giap et al., Life Sci 2002 : This study was aimed to compare the effects of selective Cox-2 inhibitor ( NS398 ) versus non-selective Cox inhibitor ( indomethacin ) on basal and basic fibroblast growth factor (bFGF) - stimulated gastric wound re-epithelialization ... These findings indicate that specific Cox-2 inhibitor ( NS398 ) does not interfere with the basal re-epithelialization but significantly inhibits the bFGF - stimulated re-epithelialization, whereas indomethacin interferes with both the basal as well as the bFGF stimulated wound re-epithelialization
Varet et al., Cell Mol Life Sci 2003 (Neovascularization, Pathologic) : At the molecular level, fenofibrate markedly decreased basic fibroblast growth factor induced Akt activation and cyclooxygenase 2 gene expression
Teh et al., J Cell Biochem 2004 (Breast Neoplasms...) : bFGF regulation of survivin expression was found to be ERK1/2 kinase dependent and bFGF induced phosphorylation of c-raf was prevented by the COX-2 inhibitor ... bFGF was, however, unable to induce COX-2 protein expression or modulate COX-2 activity in MCF-7 cells as evidenced by unaltered PGE ( 2 ) production
Watanabe et al., Dig Dis Sci 2005 (Stomach Ulcer) : COX-2 deficiency delayed ulcer healing and inhibited angiogenesis and bFGF mRNA expression in the granulation tissue
Imada et al., Int J Mol Med 2006 (Breast Neoplasms...) : COX-2 induces vascular endothelial growth factor ( VEGF ) and basic fibroblast growth factor (bFGF) and is thus involved in neovascularization
Boosani et al., Blood 2007 (Neoplasms...) : We show that binding of alpha3 ( IV ) NC1 to alpha3beta1 integrin leads to inhibition of COX-2 mediated pro-angiogenic factors, vascular endothelial growth factor, and basic fibroblast growth factor by regulating IkappaBalpha/NFkappaB axis, and is independent of alphaVbeta3 integrin
Baguma-Nibasheka et al., Mol Carcinog 2007 (Adenocarcinoma...) : Selective cyclooxygenase-2 inhibition suppresses basic fibroblast growth factor expression in human esophageal adenocarcinoma ... In this study we tested the hypothesis that the antitumor activity of COX-2 inhibitors may involve modulation of basic fibroblast growth factor ( FGF-2 ), which is overexpressed in EADC
Sales et al., Endocrinology 2007 (Adenocarcinoma...) : Furthermore, we have shown that FGF2 can promote the expression of FGF2 and cyclooxygenase-2 , and enhance proliferation of endometrial adenocarcinoma cells via the FGFR1 and ERK pathways, thereby establishing a positive feedback loop to regulate neoplastic epithelial cell function in endometrial adenocarcinomas
Gao et al., Zhonghua Yan Ke Za Zhi 2007 (Pterygium) : bFGF can induce the expression of COX-2 in HPF, COX-2 may be one of factors involved in the formation of pterygium
Luo et al., Biochem Pharmacol 2008 : Mitogen activated protein kinase kinase ( MEK ) inhibitor-PD98059 ( 10 ( -5 ) M ) markedly suppressed bFGF stimulated COX-2 expression and cell proliferation, but neither p38 MAPK inhibitor-SB203580 nor PI3K inhibitor-Wortmannin had any effect
Tjiu et al., J Invest Dermatol 2009 (Carcinoma, Basal Cell...) : Macrophages also induced COX-2 dependent secretion of basic fibroblast growth factor and vascular endothelial growth factor-A, and increased angiogenesis in BCC cells
Qian et al., Chin Med J (Engl) 2008 : The bFGF induced COX-2 upregulation led to enhanced PGE2 production by bEnd.3 cells, and this effect was abolished by the selective COX-2 inhibitor NS-398
Hughes-Fulford et al., Journal of orthopaedic surgery and research 2011 : We found that FGF-2 caused the most significant induction of expression of early growth response-1 (egr-1), fgf-2, cyclo-oxygenase-2 (cox-2) , tgfß and matrix metalloproteinase-3 (mmp-3) associated with proliferation and expression of angiogenic genes like vascular endothelial growth factor A ( vegfA ) and its receptor vegfr1
Kawaguchi et al., J Clin Invest 1995 (Bone Resorption) : bFGF stimulated PGHS-2 mRNA accumulation, which peaked at 2-4 h and then decreased ; there were later mRNA elevations at 48 and 96 h that were inhibited by indomethacin
Angerman-Stewart et al., Arch Biochem Biophys 1995 : PGHS-2 protein in the SHE cells was also increased by bFGF as determined by Western analysis using antibodies specific for PGHS-2 ... Preincubation of the cells with 1-2 microM dexamethasone significantly inhibited bFGF stimulated expression of PGHS-2 protein and mRNA
O'Banion et al., J Neurochem 1996 : TPA, basic fibroblast growth factor , and the proinflammatory factors tumor necrosis factor alpha and lipopolysaccharide, but not interleukin-6, also stimulated PGHS-2 mRNA expression
Karim et al., Biochem J 1997 : Regulatory role of prostaglandin E2 in induction of cyclo-oxygenase-2 by a thromboxane A2 analogue ( U46619 ) and basic fibroblast growth factor in porcine aortic smooth-muscle cells ... U46619, a thromboxane A2 analogue, and basic fibroblast growth factor ( FGF-2 ) both induced the expression of the inducible cyclo-oxygenase (Cox)-2 in porcine aortic smooth-muscle cells ... Cox-2 expression induced by U46619 or FGF-2 was similarly reduced by prostaglandin ( PGE2 ), forskolin or dibutyryl-cAMP, suggesting a regulatory effect of adenylate cyclase on Cox-2 expression
Rosenstock et al., Am J Physiol 1997 : The levels of PGHS-1 and PGHS-2 proteins, as measured by Western blots, were not affected by NaF or bFGF
Sasaki et al., J Clin Gastroenterol 1998 : Induction of cyclooxygenase-2 in a rat gastric epithelial cell line by epiregulin and basic fibroblast growth factor
Kage et al., Biochem Biophys Res Commun 1999 : Basic fibroblast growth factor induces cyclooxygenase-2 expression in endothelial cells derived from bone