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ANGPT2 — ETS1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Angiopoietin receptor Tie2-mediated signaling: ETS1 (ETS1) → Ang2 (ANGPT2) (transcription, activates) Krikun et al., Biochem Biophys Res Commun 2000, Fujiyama et al., Circ Res 2001, Otani et al., Diabetes 2001
  Evidence: mutant phenotype, assay, reporter gene

Text-mined interactions from Literome

Hasegawa et al., Biochem Biophys Res Commun 2004 : Transcriptional regulation of human angiopoietin-2 by transcription factor Ets-1
Watanabe et al., Am J Pathol 2004 (Anoxia...) : Dominant negative Ets-1 inhibited VEGF induced cell proliferation, tube formation, and the expression of neuropilin-1 and angiopoietin-2
Pearse et al., American journal of physiology. Renal physiology 2008 : COX-2 inhibition prevented ETS-1 expression in response to ANG II , suggesting that COX-2 is required for ETS-1 induction
Kumar et al., Ren Fail 2010 : Ang II enhances tubular cell Ets-1 expression and associated down stream signaling is mediated through AT1 receptors ... In the present study, we evaluated the effect of Ang II on the activation of Ets-1 ( a transcription factor ) in tubular cells ... In in vitro studies, Ang II enhanced mRNA expression of Ets-1 by MDCK cells
Hua et al., American journal of physiology. Renal physiology 2012 : In these studies, we determined that ANG II induces phosphorylation of ETS-1 via activation of the type 1 ANG II receptor and that Erk1/2 and Akt/PKB phosphorylation are required for these effects