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CAV1 — RAC1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zuo et al., Arterioscler Thromb Vasc Biol 2005
(Hypertrophy) :
Ang II stimulates tyrosine phosphorylation of Sos-1, a Rac-guanine nucleotide exchange factor, which is inhibited by Cav1 siRNA, demonstrating
involvement of
Cav1 in
Rac1 activation
Nethe et al., J Cell Sci 2010
:
Using Cav1-deficient mouse fibroblasts and depletion of Cav1 expression in human epithelial and endothelial cells mediated by small interfering RNA and short hairpin RNA, we show that loss of
Cav1 induces an increase in
Rac1 protein and its activated, GTP bound form ...
Cav1 controls
Rac1 protein levels by regulating ubiquitylation and degradation of activated Rac1 in an adhesion dependent fashion
Nethe et al., Cell Adh Migr 2011
:
We have recently shown that activated
Rac1 can localize to FAs and can
initiate the accumulation of the adapter protein
Caveolin1 (Cav1) at FAs
Shao et al., PloS one 2013
:
Caveolin-1 regulates
Rac1 activation and rat pulmonary microvascular endothelial hyperpermeability induced by TNF-a ... The activity of
Rac1 has been shown to be
regulated by
caveolin-1 ... In conclusion, our data suggest a mechanism for the
regulation of
Rac1 activity by
caveolin-1 , with consequences for activation of endothelial cells in response to TNF-a