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SETD2 — SRC

Text-mined interactions from Literome

Karni et al., J Biol Chem 2002 : Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia
Bendinelli et al., Mol Cancer Res 2009 (Bone Neoplasms...) : After c-Src wild-type (Srcwt) transfection, c-Src-signal transducer overexpression in 1833 cells increased HIF-1 transactivating activity and invasiveness, and changed E-cadherin/N-cadherin ratio versus mesenchymal phenotype
Lee et al., Carcinogenesis 2011 (Anoxia) : Src activates HIF-1a not through direct phosphorylation of HIF-1a specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway ... We found that excess vitamin C treatment attenuates Src induced HIF-1a activation
Hanna et al., J Clin Invest 2013 (Anoxia...) : HIF1a and HIF2a independently activate SRC to promote melanoma metastases ... HIF1a and HIF2a drive melanoma invasion and invadopodia formation through PDGFRa and focal adhesion kinase mediated ( FAK mediated ) activation of SRC and by coordinating ECM degradation via MT1-MMP and MMP2 expression
Jiang et al., Cancer Res 1997 (Disease Progression...) : V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1 : involvement of HIF-1 in tumor progression ... In this report, we demonstrate that whereas C-SRC expression is not required for expression of HIF-1 or transcriptional activation of genes encoding VEGF and enolase 1 (ENO1), cells expressing the v-Src oncogene have increased expression of HIF-1, VEGF, and ENO1 under both hypoxic and nonhypoxic conditions