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EGF — FGF1
Text-mined interactions from Literome
Thomas et al., Arthritis Rheum 2000
:
Tumor necrosis factor alpha, interleukin-6, and
epidermal growth factor did not
increase aFGF expression in vitro ; in contrast, transforming growth factor beta1 ( TGFbeta1 ) was found to markedly increase aFGF production by cultured synovial cells
Hienola et al., Mol Cell Neurosci 2004
:
Further, our in vitro studies show that exogenously added HB-GAM inhibits formation and growth of FGF-2, but not
EGF , stimulated neurospheres, restricts the number of nestin positive neural stem cells, and
inhibits FGF receptor phosphorylation
Horiguchi et al., Endocrine 2004
:
Basic
FGF and EGF did not modulate changes in VEGF-A mRNA levels after 4 and 24 h of treatment, but
EGF increased VEGF-A significantly ( p < 0.05 ) after 96 h of treatment
Fiorelli et al., J Clin Endocrinol Metab 1989
(Prostatic Hyperplasia) :
EGF binding was
inhibited by excess EGF, but not by insulin, proinsulin,
fibroblast growth factor , or insulin-like growth factors I and II
Shipley et al., J Cell Physiol 1989
:
In comparison, heparin slightly inhibited the stimulatory
effect of
aFGF and had no effect on
epidermal growth factor (EGF) stimulation in keratinocyte cultures
Kan et al., Proc Natl Acad Sci U S A 1989
:
An
EGF/TGF-alpha dependent change in HBGF-1 receptor phenotype and increasing levels of nonparenchymal-cell derived
HBGF-1 and TGF-beta may serve to limit hepatocyte proliferation
Hicks et al., Biochem Biophys Res Commun 1989
:
However, unlike phorbol esters,
aFGF and bFGF
inhibit EGF binding in protein kinase C-deficient cells ... In contrast to bombesin but like PDGF, neither
aFGF nor bFGF
act on the
EGF receptor through a pertussis toxin-sensitive G protein
Gospodarowicz et al., J Cell Physiol 1977
:
With chondrocytes, both FGF and
EGF are mitogenic and
FGF 's, but not EGF 's effect is
potentiated by dexamethasone
Balk et al., Life Sci 1984
:
While EGF alone at 100 ng/ml causes threefold multiplication at four days and brain FGF causes a sixfold increase,
EGF acts synergistically with Sm-C/IGF-I, MSA/rIGF-II, insulin or proinsulin to cause 18-fold multiplication, and brain
FGF acts synergistically with IGFs to cause 20-fold multiplication
Lau et al., Tissue Cell 1993
:
Further studies show that
EGF , TGF-alpha, aFGF, and PDGF increased the total numbers of heart cells, and that
aFGF and PDGF also
increased the percentages of heart muscle cells
Yamagata et al., Clin Exp Pharmacol Physiol 1995
(Cerebrovascular Disorders...) :
EGF induced greater DNA synthesis in SHRSP and SHRSR astrocytes compared with WKY astrocytes, although
FGF had little or no effect