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C3AR1 — IFNG

Text-mined interactions from Literome

Gutzmer et al., Immunology 2004 : In this study, we demonstrated the expression of the C3aR on human monocyte derived dendritic cells ( MoDC ) and its up-regulation by interferon ( IFN ) -alpha, IFN-gamma and prostaglandin E2 ( PGE2 ) ... After up-regulation of the C3aR by IFN-alpha+ IFN-gamma , C3a significantly up-regulated the surface expression of CD54, CD83 and CD86, but not of CD40, CD80 or human leucocyte antigen ( HLA ) -DR. C3a had no effect on the production of interleukin (IL)-10 or IL-12p70, or on the capacity of MoDC to stimulate autologous T-cell proliferation
Burg et al., J Immunol 1996 : For U937 cells, IFN-gamma and Bt2cAMP up-regulated the C3aR to the same extent, whereas Bt2cAMP was 20-fold more effective in C5aR induction ... Despite comparable numbers of both receptors, IFN-gamma potentiated activation of the C5aR but not the C3aR , as measured by an increase in free cytosolic Ca2+ upon ligand activation