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BRCA1 — H2AFX

Pathways - manually collected, often from reviews:

• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1/ABRA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1-FAM175A) (modification, collaborate)
  Wang et al., Science 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → ABRA1 (FAM175A) (modification, collaborate) Wang et al., Science 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1/ABRA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1-FAM175A) → ABRA1 (FAM175A) (modification, collaborate) Wang et al., Science 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Fanconi anemia pathway: BRCA1 (BRCA1) → FANCD2/FANCI/H2AX complex (FANCD2-FANCI-H2AFX) (modification, activates)
  Bogliolo et al., EMBO J 2007*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Fanconi anemia pathway: BRCA1 (BRCA1) → H2AX (H2AFX) (modification, activates) Bogliolo et al., EMBO J 2007*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → MRN complex/ATM/MDC1/H2AX/RNF8/53BP1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1) (modification, collaborate)
  Cortez et al., Science 1999, Li et al., Nature 2000, Xu et al., Mol Cell Biol 2001, Stewart et al., Nature 2003, Lou et al., J Biol Chem 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → CtBP/CtIP complex (RBBP8) (modification, collaborate) Cortez et al., Science 1999, Li et al., Nature 2000, Xu et al., Mol Cell Biol 2001, Stewart et al., Nature 2003, Lou et al., J Biol Chem 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Cortez et al., Science 1999, Li et al., Nature 2000, Xu et al., Mol Cell Biol 2001, Stewart et al., Nature 2003, Lou et al., J Biol Chem 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Cortez et al., Science 1999, Li et al., Nature 2000, Xu et al., Mol Cell Biol 2001, Stewart et al., Nature 2003, Lou et al., J Biol Chem 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1/ABRA1/RAP80 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1-FAM175A-UIMC1) → RAP80 (UIMC1) (modification, collaborate) Wang et al., Science 2007, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1/ABRA1/RAP80 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1-FAM175A-UIMC1) → MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1/ABRA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1-FAM175A) (modification, collaborate)
  Wang et al., Science 2007, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database ATM pathway: RAP80 (UIMC1) → MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1/ABRA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1-FAM175A) (modification, collaborate)
  Wang et al., Science 2007, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → SMC1 (SMC1A) (modification, activates) Kim et al., Genes Dev 2002, Yazdi et al., Genes Dev 2002, Kitagawa et al., Genes Dev 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → SMC3 (SMC3) (modification, activates) Luo et al., J Biol Chem 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → MRN complex/ATM/MDC1/H2AX/RNF8/53BP1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1) (modification, collaborate)
  Li et al., Nature 2000, Xu et al., Cancer Res 2002, Stewart et al., Nature 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → CtBP/CtIP complex (RBBP8) (modification, collaborate) Li et al., Nature 2000, Xu et al., Cancer Res 2002, Stewart et al., Nature 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Li et al., Nature 2000, Xu et al., Cancer Res 2002, Stewart et al., Nature 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Li et al., Nature 2000, Xu et al., Cancer Res 2002, Stewart et al., Nature 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: BRCA1 → H2AFX (indirect_complex) Masson et al., EMBO J 1999, Yamane et al., Mol Cell Biol 2002*, Wang et al., Science 2002*, West et al., Nat Rev Mol Cell Biol 2003*, Sehorn et al., Nature 2004, Oliver-Bonet et al., Mol Hum Reprod 2005, Thorslund et al., EMBO J 2007, Oliver-Bonet et al., Mol Hum Reprod 2007, Sheridan et al., Nucleic Acids Res 2008, Garcia-Cruz et al., Reprod Biomed Online 2009, Okorokov et al., PloS one 2010, Scully et al., Cell 1997, Barlow et al., EMBO J 1997, Golub et al., Nucleic Acids Res 1998
• Reactome Reaction: BRCA1 → H2AFX (reaction) Ward et al., J Biol Chem 2001, Yamane et al., Mol Cell Biol 2002*, Wang et al., Science 2002*, West et al., Nat Rev Mol Cell Biol 2003*, Garcia-Cruz et al., Reprod Biomed Online 2009, Scully et al., Cell 1997

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: H2AFX — BRCA1 (physical association, affinity chromatography technology) Tsai et al., Nat Cell Biol 2008*
• IRef Biogrid Interaction: H2AFX — BRCA1 (colocalization, imaging technique) Paull et al., Curr Biol 2000*
• IRef Biogrid Interaction: H2AFX — BRCA1 (direct interaction, pull down) Mallery et al., EMBO J 2002*
• IRef Biogrid Interaction: H2AFX — BRCA1 (colocalization, imaging technique) Mok et al., Cell Signal 2010*
• IRef Biogrid Interaction: H2AFX — BRCA1 (colocalization, imaging technique) Nelson et al., Radiat Res 2010*
• IRef Biogrid Interaction: H2AFX — BRCA1 (direct interaction, pull down) Chen et al., J Biol Chem 2002
• IRef Biogrid Interaction: H2AFX — BRCA1 (physical association, affinity chromatography technology) Ray et al., Mol Cell Biol 2009*
• IRef Intact Interaction: Complex of H2AFX-PALB2-RAD51-MORF4L1-LMNA-BRCA1-BRCA2 (colocalization, cosedimentation through density gradient) Bleuyard et al., EMBO Rep 2012
• IRef Intact Interaction: BRCA1 — H2AFX (colocalization, fluorescence microscopy) Huen et al., Cell 2007
• IRef Intact Interaction: BRCA1 — H2AFX (colocalization, confocal microscopy) Mailand et al., Cell 2007
• IRef Intact Interaction: BRCA1 — H2AFX (physical association, coimmunoprecipitation) Kobayashi et al., Curr Biol 2002*

Text-mined interactions from Literome

Tres et al., Mol Reprod Dev 2005 : The BRCA1-ATR kinase complex, as recent research suggests, triggers the phosphorylation of histone H2AX , which predominates in the condensed chromatin of the XY chromosomal pair
Wiltshire et al., Mol Pharmacol 2007 (Chromosome Breakage...) : We observed that irofulven induces the formation of chromosome breaks and radials and the activation and foci formation of gamma-H2AX , BRCA1 , and RAD51 ... We observed that irofulven induces the formation of chromosome breaks and radials and the activation and foci formation of gamma-H2AX , BRCA1 , and RAD51