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KRAS — MAP2K1

Pathways - manually collected, often from reviews:

• KEGG Cholinergic synapse: HRAS/KRAS/NRAS → MAP2K1 (protein-protein, activation)
• Reactome Reaction: MAP2K1 → KRAS (indirect_complex)
• Reactome Reaction: MAP2K1 → KRAS (reaction)

Text-mined interactions from Literome

Matsuo et al., Mol Cancer Res 2009 (Carcinoma, Pancreatic Ductal...) : Western blot analysis revealed that K-Ras activation promoted the phosphorylation of Raf/mitogen activated protein kinase kinase-1/2 ( MEK1/2 ) and expression of c-Jun
Van Schaeybroeck et al., Cancer Res 2011 (Colorectal Neoplasms) : Collectively, our findings indicate that oncogenic Kras regulates ADAM17 activity and thereby growth factor ligand shedding in a MEK1/2/Erk1/2 dependent manner and that KrasMT CRC tumors are vulnerable to MEK1/2 inhibitors, at least in part, due to their dependency on ADAM17 activity