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NOS1 — PARP1

Text-mined interactions from Literome

Hassa et al., J Biol Chem 2001 : Finally, we showed that PARP-1 is activating the natural inducible nitric-oxide synthase and P-selectin promoter in a kappa B-dependent manner upon stimulation of the cells with inflammatory stimuli or cotransfection of p65
Hwang et al., J Neurochem 2002 : These results suggest that NADPH oxidase and nNOS contribute to increased oxidative stress, subsequent activation of PARP/PARG , and neuronal death induced by prolonged neurotrophin exposure
Wang et al., Ann N Y Acad Sci 2003 (Disease Models, Animal...) : The mechanisms of MPTP induced neurotoxicity are not yet fully understood but involve activation of N-methyl-D-aspartate ( NMDA ) receptors by glutamate, production of NO by nNOS and iNOS, oxidative injury to DNA, and activation of the DNA damage sensing enzyme poly ( ADP-ribose ) polymerase ( PARP )
Nakajima et al., J Biol Chem 2004 (Inflammation) : PARP-1 inhibitors and the antisense RNA for PARP-1 mRNA suppressed lipopolysaccharide (LPS) induced expression of tumor necrosis factor-alpha and inducible nitric-oxide synthase , suggesting that PARP-1 activity has a critical role in synthesis
von Lukowicz et al., Cardiovasc Res 2008 (Atherosclerosis...) : PARP inhibition or PARP1 deletion reduced PARP activity and diminished expression of inducible nitric oxide synthase , vascular cell adhesion molecule-1, and P- and E-selectin
Braidy et al., Neurotox Res 2009 : We have shown that the NMDA ion channel blockers, MK801 and memantine, and the nitric oxide synthase (NOS) inhibitor, L-NAME, significantly attenuate QUIN mediated PARP activation, NAD ( + ) depletion, and LDH release in both neurons and astrocytes
Adamczyk et al., FEBS Lett 2010 : The inhibitor of Ca2+ dependent NOS ( N-nitro-L-arginine, 100 microM ) prevented ASN evoked caspase-3 activation and PARP-1 degradation