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ARF6 — RAC1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of ARF6-RAC1
→
VEGFA
(increases)
Evidence: In ECs, VEGF stimulates ARF6 association with Rac1, which is cotemporaneous with Rac1 activation.
-
KEGG Fc gamma R-mediated phagocytosis:
RAC1/RAC2
→
ARF6
(protein-protein, activation)
-
NCI Pathway Database Arf6 downstream pathway:
RAC1/GDP complex (RAC1)
→
ARF6/GTP/NME1/Tiam1 complex (NME1-TIAM1-ARF6)
(modification, collaborate)
Palacios et al., Nat Cell Biol 2002, Michiels et al., Nature 1995*
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database Arf6 downstream pathway:
ARF6/GTP complex (ARF6)
→
RAC1/GDP complex (RAC1)
(translocation, activates)
Tushir et al., EMBO J 2007
Evidence: mutant phenotype
-
NCI Pathway Database Arf6 downstream pathway:
ARF6/GTP complex (ARF6)
→
RAC1/GTP complex (RAC1)
(cortical actin cytoskeleton organization, activates)
Radhakrishna et al., J Cell Sci 1999*, D'Souza-Schorey et al., EMBO J 1997*
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
RAC1/GDP complex (RAC1)
→
ARF6/GTP/NME1/Tiam1 complex (NME1-TIAM1-ARF6)
(modification, collaborate)
Nakagawa et al., J Cell Sci 2001, Noren et al., J Biol Chem 2001, Kovacs et al., J Biol Chem 2002, Palacios et al., Nat Cell Biol 2002, Fukuyama et al., Oncogene 2006
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database Class I PI3K signaling events:
RAC1/GTP complex (RAC1)
→
ARF6/GDP complex (ARF6)
(actin cytoskeleton reorganization, activates)
Krugmann et al., J Cell Sci 2006*, Hawkins et al., Curr Biol 1995*
Evidence: mutant phenotype
-
NCI Pathway Database Arf6 downstream pathway:
RAC1/GDP complex (RAC1)
→
ARF6/GTP complex (ARF6)
(modification, collaborate)
Koo et al., BMC cell biology 2007*
Evidence: mutant phenotype
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Palacios et al., J Biol Chem 2003
:
We have found that an initial
ARF6 dependent decrease in the levels of
Rac1-GTP is necessary to induce cell-cell dissociation
Conger et al., Ren Fail 1992
(Acute Kidney Injury...) :
Functionally similar ischemic
acute renal failure ( ARF ) , as estimated by glomerular filtration rates ( GFR ), was
induced by
renal artery clamping ( RAC ) or intrarenal norepinephrine ( NE ) in rats and renovascular reactivity was examined at 1 week
Ikeda et al., Circ Res 2005
(Ischemia) :
In this study, we show that overexpression of dominant negative
ARF6 [ ARF6 ( T27N ) ] almost completely
inhibits VEGF induced
Rac1 activation, ROS production, and VEGFR2 autophosphorylation in ECs
Santy et al., Curr Biol 2005
:
ARF6 is intimately involved in the regulation of Rac activity ; however, the mechanisms by which
ARF activation
leads to activation of
Rac remain poorly understood ...
ARF6 is intimately
involved in the regulation of
Rac activity ; however, the mechanisms by which ARF activation leads to activation of Rac remain poorly understood
Tushir et al., EMBO J 2007
:
ARF6 dependent
activation of ERK and
Rac1 modulates epithelial tubule development ... Second,
ARF6 induced ERK activation
regulates Rac1 activation during tubule initiation through the expression of the receptor for urokinase type plasminogen activator
Koo et al., BMC cell biology 2007
:
Although
Arf6 facilitates the trafficking of Rac1 to the plasma membrane and in many cases Arf6 activation
leads to the activation of
Rac1 , the details of how Arf6 influences Rac function remain to be elucidated ... Kalirin5 induced
Rac1 activation is
increased by the expression of wild type
Arf6 and decreased by Arf6T27N ... Although Kalirin is recruited onto membranes by Arf6-GDP, subsequent
Rac activation and membrane ruffling
requires Arf6 activation ... From these results, we suggest that
Arf6 can
regulate through its GTPase cycle the activation of
Rac
Hall et al., Anal Biochem 2008
:
The
involvement of the small GTPase
Arf6 in
Rac activation, cell migration, and cancer invasiveness suggests that it is activated in a spatially and temporally regulated manner
Hu et al., Cancer Res 2009
(Brain Neoplasms...) :
ARF6 forms complexes with Rac1 and IQGAP1 in glioma cells upon HGF stimulation, and knockdown of IQGAP1 significantly
inhibits ARF6 induced
Rac1 activation and cell migration ... Taken together, these data suggest that
ARF6 mediated
Rac1 activation is essential for glioma cell invasion via a signaling pathway that requires IQGAP1