Gene interactions and pathways from curated databases and text-mining

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ARF6 — RAC1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Palacios et al., J Biol Chem 2003 : We have found that an initial ARF6 dependent decrease in the levels of Rac1-GTP is necessary to induce cell-cell dissociation
Conger et al., Ren Fail 1992 (Acute Kidney Injury...) : Functionally similar ischemic acute renal failure ( ARF ) , as estimated by glomerular filtration rates ( GFR ), was induced by renal artery clamping ( RAC ) or intrarenal norepinephrine ( NE ) in rats and renovascular reactivity was examined at 1 week
Ikeda et al., Circ Res 2005 (Ischemia) : In this study, we show that overexpression of dominant negative ARF6 [ ARF6 ( T27N ) ] almost completely inhibits VEGF induced Rac1 activation, ROS production, and VEGFR2 autophosphorylation in ECs
Santy et al., Curr Biol 2005 : ARF6 is intimately involved in the regulation of Rac activity ; however, the mechanisms by which ARF activation leads to activation of Rac remain poorly understood ... ARF6 is intimately involved in the regulation of Rac activity ; however, the mechanisms by which ARF activation leads to activation of Rac remain poorly understood
Tushir et al., EMBO J 2007 : ARF6 dependent activation of ERK and Rac1 modulates epithelial tubule development ... Second, ARF6 induced ERK activation regulates Rac1 activation during tubule initiation through the expression of the receptor for urokinase type plasminogen activator
Koo et al., BMC cell biology 2007 : Although Arf6 facilitates the trafficking of Rac1 to the plasma membrane and in many cases Arf6 activation leads to the activation of Rac1 , the details of how Arf6 influences Rac function remain to be elucidated ... Kalirin5 induced Rac1 activation is increased by the expression of wild type Arf6 and decreased by Arf6T27N ... Although Kalirin is recruited onto membranes by Arf6-GDP, subsequent Rac activation and membrane ruffling requires Arf6 activation ... From these results, we suggest that Arf6 can regulate through its GTPase cycle the activation of Rac
Hall et al., Anal Biochem 2008 : The involvement of the small GTPase Arf6 in Rac activation, cell migration, and cancer invasiveness suggests that it is activated in a spatially and temporally regulated manner
Hu et al., Cancer Res 2009 (Brain Neoplasms...) : ARF6 forms complexes with Rac1 and IQGAP1 in glioma cells upon HGF stimulation, and knockdown of IQGAP1 significantly inhibits ARF6 induced Rac1 activation and cell migration ... Taken together, these data suggest that ARF6 mediated Rac1 activation is essential for glioma cell invasion via a signaling pathway that requires IQGAP1