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PIK3R1 — PIP
Text-mined interactions from Literome
Xie et al., Mol Biol Cell 2005
:
These data indicate that calcium activates PLC-gamma1 via increased
PIP3 formation
mediated by c-src- and fyn activated
PI3K
Etkovitz et al., Biol Reprod 2007
:
On the other hand, activation of PKC by phorbol myristate acetate
enhanced PIP ( 2 ( 4,5 ) ) and F-actin formation mediated by PI4K activity, while the
PI3K activity and intracellular PIP ( 3 ( 3,4,5 ) ) levels were reduced
Yamamoto et al., Biomed Res 2008
(Ion Channel Gating) :
These results suggest that the activation of VRAC current requires the presence of intracellular PIP3, that
PI3K mediated increase in
PIP3 level is sufficient to fully activate VRAC current, and that PIP3 alone without osmotic stimulation can not induce VRAC current
Bandara et al., PLoS Comput Biol 2009
:
The experimental approach included the activation of endogenous phosphoinositide 3-kinase (PI3K) by chemically induced recruitment of a regulatory peptide, reversible inhibition of PI3K using a kinase inhibitor, and monitoring of the
PI3K mediated production of
PIP ( 3 ) lipids using the pleckstrin homology (PH) domain of Akt