◀ Back to TNF

JAK2 — TNF

Text-mined interactions from Literome

Han et al., J Interferon Cytokine Res 1999 : In TNF-alpha treated cells, IFN-gamma induced phosphorylation of Jak2 kinase is increased, Jak2 kinase activity is enhanced, and genetic studies indicate that TNF-alpha requires Jak2 kinase activity to enhance Stat1alpha tyrosine phosphorylation
Rojas et al., Cell Immunol 2002 : Inhibitors of PTK ( AG-126 ), or JAK2 ( AG-490 ) inhibited TNF-alpha and NO production, caspase 1 activation and apoptosis, suggesting that M. tuberculosis-induction of these events depends on JAK2/STAT1-alpha activation
Fasshauer et al., J Endocrinol 2004 (Insulin Resistance) : Furthermore, stimulation experiments and studies using pharmacologic inhibitors suggested that the positive effect of TNFalpha , GH and IL-6 on SOCS-1 mRNA is, at least in part, mediated by Janus kinase (Jak) 2
Ait-Ali et al., Mol Endocrinol 2004 : Stimulatory effects of TNF-alpha on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor, and required activation of ERK 1/2 and p38, but not Janus kinase , MAPKs
Han et al., J Immunol 2006 (Gram-Positive Bacterial Infections) : Jak2 tyrosine kinase inhibition blocked LTA induced production of NO but not TNF-alpha
Ahmed et al., Am J Physiol Gastrointest Liver Physiol 2006 : TNF attenuated JAK2/STAT5 and ERK1/2 phosphorylation and IGF-I and Spi 2.1 mRNA expression following GH stimulation
Rafail et al., Thromb Res 2008 (Inflammation...) : Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2 dependent mechanisms and TNFalpha involvement
Pincheira et al., J Immunol 2008 : Stimulation with TNF induces a time dependent change in the level of Jak2 , c-Src, and PI3K associated with TNFR1 ... TNFR1/c-Src, but not TNFR1/Jak2 , plays an obligate role in the activation of NF-kappaB by TNF , whereas TNFR1/Jak2, but not TNFR1/c-Src, plays an obligate role in the activation of STAT3
Betts et al., Blood 2011 : JAK2 inhibition also reduces the production of IL-6 and TNF-a in allogeneic MLRs, impairing the activation of central and effector memory T cells as well as the expansion of responder Th1 and Th17 cells
Yarilina et al., Arthritis Rheum 2012 (Arthritis, Rheumatoid...) : Our findings demonstrate that JAK inhibitors suppress macrophage activation and attenuate TNF responses and further suggest that suppression of cytokine/chemokine production and innate immunity contribute to the therapeutic efficacy of JAK inhibitors
Nam et al., J Pept Sci 2012 : Inhibition of JAK ( STAT1/STAT5 kinase ) with AG490 markedly reduced the production of IL-6 and TNF-a in macrophages
Guo et al., J Immunol 1998 : Induction of Jak/STAT signaling by activation of the type 1 TNF receptor ... In this study, we show that murine TNF induces the tyrosine phosphorylation and activation of the intracellular Janus tyrosine kinases Jak1, Jak2 , and Tyk2 in murine 3T3-L1 adipocytes ... Phosphorylation of Jak proteins was also induced by human TNF , which selectively binds to TNFR1 on murine cells