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IL10 — MMP14
Text-mined interactions from Literome
Meisser et al., Mol Hum Reprod 1999
:
The aim of this study was to determine the
effects of tumour necrosis factor alpha (TNF),
interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of
matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
John et al., Exp Lung Res 2002
(Pneumonia, Bacterial...) :
The endogenous production of IL-10 in AM of patients with sarcoidosis and the MMP downregulation by exogenous IL-10 suggest an
involvement of
IL-10 in
MMP regulation
Moalli et al., Am J Obstet Gynecol 2002
:
Membrane type 1 matrix metalloproteinase was not
affected by estradiol, ICI 182 780,
interleukin-1 beta, or transforming growth factor-beta 1
Stearns et al., Clin Cancer Res 2003
(Prostatic Neoplasms) :
Interleukin 10 blocks matrix metalloproteinase-2 and
membrane type 1-matrix metalloproteinase synthesis in primary human prostate tumor lines ... In this paper, we showed that
IL-10 activation of the IL-10 receptor
blocked MMP-2 and membrane type 1
(MT1) -MMP transcription and protein synthesis in nonimmortalized primary human prostate cell strains ( i.e., HPCA-10a and HPCA-10c ) derived from high-grade cancer ... The data show that
IL-10 blocks IGF-I
activation of MMP-2 and
MT1-MMP mRNA expression and protein synthesis in primary prostate cell strains
Sun et al., Connect Tissue Res 2003
(Arthritis, Rheumatoid) :
Furthermore, the
induction of the
MMP expression and activities by
interleukin-1 was suppressed by the oscillatory shear
Perianayagam et al., Eur J Clin Invest 2005
(Uremia) :
We hypothesized that previously reported defective synthesis of
IL-10 by immunocompetent cells exposed to a uraemic milieu may be
due to impaired mitochondrial
membrane potential ( MMP )
Hu et al., Zhonghua Xin Xue Guan Bing Za Zhi 2008
(Myocardial Infarction...) :
In vivo myocardial
IL-10 transfer
reduced myocardial
MMP and collagen expression and increasing the TIMP expression
Coussens et al., Immunology 2009
(Tuberculosis) :
We therefore determined the effects of 1alpha,25 ( OH ) ( 2 ) D ( 3 ) on expression, secretion and activity of a number of MMP and TIMP in M. tuberculosis infected human leucocytes ; we also investigated the effect of 1alpha,25 ( OH ) ( 2 ) D ( 3 ) on the secretion of
interleukin-10 (IL-10) and prostaglandin E ( 2 ) ( PGE ( 2 ) ), both transcriptional
regulators of
MMP expression
Stearns et al., Invasion Metastasis 1997
(Bone Neoplasms...) :
However
IL-10 may
inhibit the production of
matrix metalloproteases ( MMP ) and prevent the establishment of metastasis
Wagner et al., J Neurooncol 1998
(Brain Neoplasms...) :
In all but one cell line no
enhancement of
MMP expression by
IL-10 was detected