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GGA1 — NOS1
Text-mined interactions from Literome
Rokutan et al., J Gastroenterol 2000
:
In contrast,
GGA and EGF
induced neuronal NOS , but not endothelial NOS, which was confirmed by immunoblot analyses with antibodies against these constitutive NOS isoforms
Yokoi et al., J Neurochem 1994
:
The
effects of
alpha-guanidinoglutaric acid ( GGA ) , the levels of which were increased in the cobalt induced epileptic focus tissue in the cerebral cortex of cats, on brain
nitric oxide synthase (NOS) activity were observed ...
GGA inhibited
NOS activity in a linear mixed manner ( Ki = 2.69 microM ) and was as effective as NG-monomethyl-L-arginine ( MeArg ; Ki = 3.51 microM ), a well-known NOS inhibitor
Habu et al., Biochem Mol Biol Int 1996
(Seizures) :
We evaluated the effect of manipulation of nitric oxide ( NO ) synthesis on epileptiform discharges recorded from immobilized rats during intracerebroventricular injection of
alpha-guanidinoglutaric acid ( GGA ) , an endogenous convulsant and a
NO synthase (NOS) inhibitor , alone or in combined with a NOS substrate, l-arginine ( ARG )