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CRP — TNF

Text-mined interactions from Literome

Szalai et al., J Immunol 2002 (Encephalomyelitis, Autoimmune, Experimental) : Human CRP has three effects on cultured encephalitogenic cells that could contribute to the protective effect observed in vivo : 1 ) CRP inhibits encephalitogenic peptide induced proliferation of T cells ; 2 ) CRP inhibits production of inflammatory cytokines ( TNF-alpha , IFN-gamma ) and chemokines ( macrophage-inflammatory protein-1alpha, RANTES, monocyte chemoattractant protein-1 ) ; and 3 ) CRP increases IL-10 production
Smith et al., Clin Exp Immunol 1992 : IL-1 beta was the more potent inducer for SAA production, but for CRP production IL-1 alpha and IL-1 beta were equivalent ; ( iii ) prednisolone enhances the production of SAA by HepG2 cells, but does not enhance the production of CRP ; ( iv ) TNF-alpha in the presence or absence of IL-6 and/or prednisolone did not induce the production of SAA or CRP by HepG2 cells
Li et al., Clin Chim Acta 2005 (Angina, Unstable) : CRP induced the enhanced release of IL-6 and tnf-alpha by 17-fold and 23-fold increase, respectively, in patients with unstable angina, while it did about 11-fold and 19-fold increase in patients with stable angina and normal group ( IL-6 : 3129+/-333 vs. 991+/-134 and 987+/-102 pg/ml, p < 0.01, respectively ; tnf-alpha : 1554+/-784 vs. 560+/-135 and 558+/-152 pg/ml, p < 0.01, respectively )
Wang et al., Clin Chim Acta 2005 : CRP increased the release of TNF-alpha rapidly as a dose-and time dependent manner
Ganapathi et al., J Immunol 1991 (Carcinoma, Hepatocellular...) : TNF-alpha alone had no significant effect on synthesis of either SAA or CRP , but the combination of IL-6 plus TNF-alpha led to substantial induction of SAA
Mold et al., J Immunol 2006 : CRP dramatically increased the production of TNF-alpha and IL-1beta in response to S. pneumoniae
Haider et al., Clin Exp Immunol 2006 (Endotoxemia) : LPS, interleukin (IL)-1, IL-6 and tumour necrosis factor (TNF)-alpha increased and IL-10 reduced CRP expression in PBMC
Nabata et al., Atherosclerosis 2008 (Atherosclerosis) : In human mononuclear cells, CRP induced production of tumor necrosis factor-alpha (TNF-alpha) , interleukin-1 beta (IL-1 beta), and matrix metalloproteinase-9 (MMP-9) in a concentration dependent manner
Yoshizaki et al., Yakugaku Zasshi 2009 (Autoimmune Diseases...) : The results, indicated that the IL-6 signal was essential though the activation of STAT3 for the induction and augmentation of CRP or SAA by the associated stimulation with TNF-alpha or IL-1
McNair et al., Mol Cell Biochem 2010 (Myocardial Infarction) : High sensitivity C-reactive protein ( hs-CRP ) is synthesized mainly by hepatocytes in response to tumor necrosis factor-alpha (TNF-alpha) , interleukin-1 (IL-1), and interleukin-6 (IL-6)
Liou et al., J Microbiol Immunol Infect 2010 (Lupus Erythematosus, Systemic) : We have previously reported that lupus monocytes display distinctively differing patterns of C-reactive protein (CRP) inducing cytokine interleukin (IL)-6, IL-1beta, and tumor necrosis factor (TNF)-alpha secretion when stimulated with either immune complexes ( ICs ) or lipopolysaccharide (LPS)
Liu et al., Inflammation 2011 (Atherosclerosis) : C-reactive protein induces TNF-a secretion by p38 MAPK-TLR4 signal pathway in rat vascular smooth muscle cells ... Herein, our studies focused on characterizing the effect of CRP on tumor necrosis factor a (TNF-a) production and TLR4 related molecular mechanisms in rat vascular smooth muscle cells ( VSMCs ) ... TLR4 knockdown significantly inhibited CRP induced TNF-a generation, and p38 mitogen activated protein kinase ( MAPK ) blocker SB203580 depressed TLR4 expression and TNF-a production initiated by CRP in VSMCs ... The data demonstrate that CRP triggers an inflammatory response in rat VSMCs by inducing TNF-a secretion, which is mediated by p38 MAPK-TLR4 signaling pathway
Sato et al., Inflammation 2013 : When human PBMCs were stimulated in vitro with penicillin treated Streptococcus pyogenes, bacterial DNA motifs and lipopolysaccharide with or without synthetic CRP, CRP suppressed the production of TNF-a and IL-12, but not that of IFN-?
Ueba et al., Mol Med 2013 : HBSP also attenuated CRP induced production of tumor necrosis factor (TNF)-a and matrix metalloproteinase-9 in THP-1 cells
Ganapathi et al., J Immunol 1988 : These results indicate that human SAA and CRP are induced in Hep 3B cells by products of activated monocytes but not by IL-1 beta, TNF-alpha , or some hepatocyte stimulating factor preparations and that a group of heterogeneous mechanisms are involved in the induction of the various human APP
Galve-de Rochemonteix et al., J Leukoc Biol 1993 (Lung Neoplasms) : C-reactive protein increases production of IL-1 alpha, IL-1 beta, and TNF-alpha , and expression of mRNA by human alveolar macrophages ... Accordingly, we examined the capacity of alveolar macrophages -- relatively accessible human macrophages -- to produce interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) in response to CRP