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TNF — YBX1
Text-mined interactions from Literome
Abbas et al., Cytokine 2003
:
In summary,
TNF blocks expression of osteoblast differentiation markers and
inhibits beta-glycerophosphate induced activation of the osteoblast differentiation factor
cbfa1
Zhou et al., J Bone Miner Res 2006
(Fractures, Bone) :
TNF-alpha inhibits expression of osteoblast differentiation factor
cbfa1 and osteoblast differentiation in vitro and yet TNF-alpha signaling is essential for bone fracture healing ... At the injured growth plate on day 8,
TNF-alpha inhibition
increased expression of
cbfa1 and osteocalcin and increased trabecular bone formation at the injury site