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SUPT7L — TRRAP

Pathways - manually collected, often from reviews:

• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) → nucleus (EP300/CREBBP) (transcription, activates) Greenberg et al., Oncogene 1999, Faiola et al., Mol Cell Biol 2005, Liu et al., Mol Cell Biol 2008
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database C-MYC pathway: STAF65G (SUPT7L) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database C-MYC pathway: STAF65G (SUPT7L) → TRRAP/GCN5 complex (TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database C-MYC pathway: TAF10 (TAF10) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database C-MYC pathway: TAF12 (TAF12) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database C-MYC pathway: SPT3 (SUPT3H) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database C-MYC pathway: MYC/Max complex (MYC-MAX) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database C-MYC pathway: TAF9 (TAF9) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database C-MYC pathway: MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) → TRRAP/GCN5 complex (TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) → nucleus (EP300/CREBBP) (transcription, activates) Bouchard et al., EMBO J 1999, Bouchard et al., Genes Dev 2001, Vervoorts et al., EMBO Rep 2003
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) → HSP60 (HSPD1) (transcription, activates) Frank et al., Genes Dev 2001, Liu et al., Mol Cell Biol 2008
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: SUPT7L → TRRAP (direct_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of 13 proteins Liu et al., J Biol Chem 2003
• MIPS CORUM STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex): STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex) complex (KAT2A-SF3B3-SUPT3H-SUPT7L-TADA1-TADA3-TAF10-TAF12-TAF5L-TAF6L-TAF9-TRRAP) Martinez et al., Mol Cell Biol 2001
• MIPS CORUM STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex): STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex) complex (ATXN7-KAT2A-SF3B3-SUPT3H-SUPT7L-TADA1-TADA3-TAF10-TAF12-TAF5L-TAF6L-TAF9-TRRAP) Helmlinger et al., Hum Mol Genet 2004
• IRef Corum Interaction: Complex of 14 proteins (association, anti bait coimmunoprecipitation) Helmlinger et al., Hum Mol Genet 2004
• IRef Corum Interaction: Complex of 25 proteins (association, affinity chromatography technology) Martinez et al., Mol Cell Biol 2001
• Gene Ontology Complexes STAGA complex: STAGA complex complex (SUPT7L-TADA2B-KAT2A-SUPT3H-TAF12-TAF10-TRRAP-TAF5L-TADA1-TADA3) Martinez et al., Mol Cell Biol 2001
• IRef Hprd Interaction: Complex of 145 proteins (in vivo) Martinez et al., Mol Cell Biol 2001
• IRef Intact Interaction: Complex of 30 proteins (physical association, anti tag coimmunoprecipitation) Sowa et al., Cell 2009

Text-mined interactions from Literome

Liu et al., J Biol Chem 2003 : c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation
Palhan et al., Proc Natl Acad Sci U S A 2005 (Retinal Degeneration...) : Here, we report that ataxin-7 is an integral component of the mammalian STAGA ( SPT3-TAF9-ADA-GCN5 acetyltransferase ) transcription coactivator complex, interacts directly with the GCN5 histone acetyltransferase component of STAGA, and mediates a direct interaction of STAGA with the CRX ( cone-rod homeobox ) transactivator of photoreceptor genes
Liu et al., Mol Cell Biol 2008 : STAF65gamma is required for SPT3/STAGA interaction with core Mediator and for MYC recruitment of SPT3, TAF9, and core Mediator components to the TERT promoter but is dispensable for MYC recruitment of TRRAP, GCN5, and p300 and for acetylation of nucleosomes and loading of TFIID and RNA polymerase II on the promoter