◀ Back to EPHB2
ABL1 — EPHB2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
ABL1
→
EPHB2
(decreases, EPHB2 Activity, ABL1 Activity)
Yu et al., Oncogene 2001*
Evidence: Interestingly, treatment of COS cells and B35 neuronal-like cells with ephrin-B1 to activate endogenous EphB2 decreased the kinase activity of endogenous Abl.
-
KEGG Axon guidance:
EPHB1/EPHB2/EPHB3/EPHB4/EPHB6
→
ABL1
(protein-protein, activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
EPHB2
—
ABL1
(physical association, affinity chromatography technology)
Yu et al., Oncogene 2001*
-
IRef Biogrid Interaction:
EPHB2
—
ABL1
(direct interaction, pull down)
Yu et al., Oncogene 2001*
-
IRef Biogrid Interaction:
EPHB2
—
ABL1
(direct interaction, two hybrid)
Yu et al., Oncogene 2001*
-
IRef Hprd Interaction:
EPHB2
—
ABL1
(in vivo)
Yu et al., Oncogene 2001*
-
IRef Hprd Interaction:
EPHB2
—
ABL1
(two hybrid)
Yu et al., Oncogene 2001*
-
IRef Ophid Interaction:
EPHB2
—
ABL1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
EPHB2
—
ABL1
(aggregation, confirmational text mining)
Yu et al., Oncogene 2001*
Text-mined interactions from Literome
Renshaw et al., Oncogene 2000
(MAP Kinase Signaling System) :
Expression of a kinase-defective
c-Abl specifically
inhibited the transient induction of
Erk2 activity following cell adhesion
Yu et al., Oncogene 2001
:
Activated
EphB2 causes tyrosine phosphorylation of
Abl and Arg, and vice versa
Li et al., EMBO J 2001
(MAP Kinase Signaling System) :
In vivo expression of a Grb2 mutant where Tyr209 was changed to phenylalanine enhanced
BCR/ABL induced
ERK activation and fibroblast transformation, and potentiated and prolonged Grb2 mediated activation of Ras, mitogen activated protein kinase and c-Jun N-terminal kinase in response to EGF stimulation
Wilson et al., Oncogene 2002
(Cell Transformation, Neoplastic...) :
These data implicate the Src kinase family in Stat5 and
Erk activation downstream of
Bcr-Abl , and identify myeloid-specific Src kinases as potential drug targets in CML
Baughn et al., J Virol 2005
(Cell Transformation, Viral) :
Expression of DN Shc reduced Ab-MLV pre-B-cell transformation and decreased the ability of
v-Abl to
stimulate Ras activation and
Erk phosphorylation in a Raf dependent but Rac independent fashion
Sirvent et al., Oncogene 2007
(Breast Neoplasms...) :
Moreover,
Abl mediates Src induced
extracellular regulated kinase 5 (ERK5) activation to drive cell transformation
Aceves-Luquero et al., PloS one 2009
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
In fact,
Bcr/Abl activates preferentially
Erk2 in transient transfection in a dose dependent fashion through the c-Abl part of the chimeric protein
Liu et al., Int J Cardiol 2011
(Carotid Artery Injuries...) :
In vivo,
ABL ( 26 mg/kg/day ) significantly
suppressed injury induced
ERK1/2 phosphorylation, and increased VSMC apoptosis 14 days after balloon injury
Lu et al., Cell cycle (Georgetown, Tex.) 2010
:
Here we show that Abl is necessary for p38alpha/beta activation initiated by N-cadherin ligation, but in contrast to Cdo,
Abl is also
required for N-cadherin dependent
ERK activation
Jia et al., Am J Physiol Cell Physiol 2012
(MAP Kinase Signaling System) :
Abl regulates smooth muscle cell proliferation by modulating actin dynamics and
ERK1/2 activation ... The results suggest that
Abl may
regulate smooth muscle cell proliferation by modulating actin dynamics and
ERK1/2 phosphorylation during mitogenic activation
Mokhtari et al., Diabetologia 2013
:
Imatinib stimulated
ERK ( thr202/tyr204 ) phosphorylation in a
c-Abl dependent manner
Tanaka et al., Mol Cell Biol 1995
:
These results suggest that both Crk and Grb2 may contribute to the
activation of
Erk by oncogenic
Abl , whereas Nck is unlikely to participate in this pathway