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CTNNB1 — NFKB1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
NFKB1
—
CTNNB1
Kim et al., Nature 2005
-
IRef Bind_translation Interaction:
NFKB1
—
CTNNB1
(coimmunoprecipitation)
Kim et al., Nature 2005
-
IRef Biogrid Interaction:
CTNNB1
—
NFKB1
(physical association, affinity chromatography technology)
Kim et al., Nature 2005
-
IRef Biogrid Interaction:
CTNNB1
—
NFKB1
(colocalization, imaging technique)
Kim et al., Nature 2005
-
Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
-
IRef Hprd Interaction:
CTNNB1
—
NFKB1
(in vivo)
Kim et al., Nature 2005
-
IRef Innatedb Interaction:
NFKB1
—
CTNNB1
(unknown, -)
Choi et al., Nucleic Acids Res 2007*
-
IRef Intact Interaction:
NFKB1
—
CTNNB1
(direct interaction, pull down)
Choi et al., FEBS Lett 2009*
-
IRef Intact Interaction:
NFKB1
—
CTNNB1
(physical association, anti bait coimmunoprecipitation)
Choi et al., FEBS Lett 2009*
Text-mined interactions from Literome
Spiegelman et al., Oncogene 2002
:
In the NIH3T3 cells, which express HOS, but not betaTrCP,
Wnt/beta-catenin signaling
leads to inhibition of HOS promoter activity and
NF-kappaB-driven transcription as well as to stabilization of beta-catenin
Tselepis et al., Oncogene 2002
(Adenocarcinoma...) :
This
beta-catenin mediated transcription is
independent of
NF-kappaB activation
Deng et al., Cancer Cell 2002
(Breast Neoplasms...) :
beta-catenin interacts with and
inhibits NF-kappa B in human colon and breast cancer ... Importantly, activated
beta-catenin was found to
inhibit the expression of
NF-kappa B target genes, including Fas and TRAF1 ... Furthermore, a strong inverse correlation was identified between the expression levels of beta-catenin and Fas in colon and breast tumor tissues, suggesting that
beta-catenin regulates
NF-kappa B and its targets in vivo
Deng et al., Mol Carcinog 2004
:
beta-catenin has been recently found to interact with and
inhibit nuclear factor kappa B (NF-kappaB)
Kuphal et al., Oncogene 2004
(Melanoma) :
Furthermore, cytoplasmatic
beta-catenin induced p38 and
NFkappaB activation in malignant melanoma ... In summary, we conclude that loss of E-cadherin and cytoplasmatic
beta-catenin induces p38 mediated
NFkappaB activation, potentially revealing an important mechanism of tumorigenesis in malignant melanomas
Zuscik et al., Environ Health Perspect 2007
:
Although Pb had no effect on basal CREB or
Wnt/beta-catenin pathway activity, it
induced NFkappaB signaling and inhibited AP-1 signaling
Cho et al., FEBS Lett 2008
(Neoplasms) :
Downregulation of lzts2 increased the beta-catenin/Tcf promoter activity and inhibited
NF-kappaB induced modulation of the nuclear translocation of
beta-catenin
Zhang et al., Dev Cell 2009
:
We find that
Wnt/beta-catenin signaling is absolutely
required for
NF-kappaB activation, and that Edar is a direct Wnt target gene