Gene interactions and pathways from curated databases and text-mining

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IRF6 — JUN

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Chen et al., Immunology 1999 : LPS activation of nuclear factor-kappa B (NF-kappaB), activator protein-1 (AP-1) and p38 MAPK was also inhibited by SB 203580
Imai et al., FEBS Lett 1999 : Since recent studies showed that c-Jun N-terminal kinase (JNK) , one of the mitogen activated protein kinases, plays an important role in LPS signalling, we focused here on the inhibitory action of TGF-beta1 on LPS stimulated JNK activity in mouse macrophages
Kim et al., Cancer Res 2000 (MAP Kinase Signaling System) : Furthermore, IRF7 was activated by the c-Jun NH2-terminal kinase (JNK) in response to DNA damaging agents
Steer et al., J Biol Chem 2000 : LPS increased nuclear c-Jun/ATF-2 , NF-kappaB ( 1 ) /Rel-A, and Rel-A/C-Rel transcription factor complexes, which bound specifically to oligonucleotide sequences from the -106 to -88 base pair ( bp ) region of the promoter
Tengku-Muhammad et al., Cytokine 2000 : The regulation of macrophage activator protein-1 (AP-1) gene expression by LPS and cytokines is of potentially crucial importance in the pathogenesis of several diseases
Simoncini et al., Circ Res 2000 : Consistently, gel-shift assays showed that E ( 2 ) and Dex comparably inhibit LPS induced activation of NF-kappaB, whereas E ( 2 ) inhibited LPS induced activation of AP-1 and GATA to a greater extent than Dex
Lakics et al., J Immunol 2000 : Although the composition of NF-kappaB complexes detected by EMSA and supershift analysis in nuclear lysates derived from Bcl-xL transfectants and control cells was indistinguishable, LPS induced inhibitory kappaBalpha degradation, as well as NF-kappaB binding and AP-1 activation, were slightly decreased by ectopic expression of Bcl-xL
Jeon et al., Immunopharmacology 2000 : Third, angelan induced strong NF-kappaB/Rel and slight AP-1 DNA binding, whereas LPS potently activated both NF-kappaB/Rel and AP-1
Procyk et al., Blood 2000 : The activation of Jun N-terminal kinases (JNK) by LPS is herbimycin sensitive
Shen et al., J Immunol 2001 : We demonstrate that AP-1 ( Fos and Jun ), induced transiently by CD40 ligand or LPS , binds a DNA element in the mouse GL epsilon promoter
Hsu et al., J Immunol 2001 : The nuclear translocation and DNA binding study revealed that ceramide can inhibit LPS induced NF-kappaB and AP-1 activation
Møller et al., Thromb Res 2001 : Finally, both LPS and AraLAM activated the `` early immediate genes '' through translocation of the transcription factor proteins NF-kappaB/Rel and increasing the binding activity of AP-1
Jones et al., J Leukoc Biol 2001 (MAP Kinase Signaling System) : Stimulation of RAW 264.7 macrophages by LPS , LAM, STF, and PIM rapidly activated nuclear factor (NF)-kappaB, activator protein-1 (AP-1) , and mitogen activated protein ( MAP ) kinases
García-Lora et al., Cancer Immunol Immunother 2001 : Here we report that PSK enhanced AP-1 and CRE binding activities, whereas IL-2 increased AP-1 and SP-1 and modified GAS/ISRE, IRF-1 and STAT5
Supajatura et al., J Immunol 2001 (Acute Disease...) : TLR4 mediated stimulation of mast cells by LPS was followed by activation of NF-kappaB but not by stress activated protein kinase/c-Jun NH2-terminal kinase signaling
Matsumura et al., Life Sci 2001 : However, activation of activator protein-1 (AP-1) , which is also contained in the iNOS promoter, was not enhanced by LPS/IFN or inhibited by DEX
Yi et al., Int Immunol 2001 : In addition, CpG DNA showed little or no enhancement of LPS mediated AP-1 activation
Simonin et al., Am J Physiol Cell Physiol 2002 : Troglitazone had no effect on NF-kappa B activation and was shown to increase LPS induced AP-1 activation
Galdiero et al., Infect Immun 2002 (MAP Kinase Signaling System) : PD-098059 pretreatment of cells decreases AP-1 and NF-kappaB activation by lipopolysaccharide (LPS) but not by porins, and SB203580 pretreatment of cells decreases mainly AP-1 and NF-kappaB activation by porins ; in contrast, forskolin pretreatment of cells does not affect AP-1 and NF-kappaB activation following either porin or LPS stimulation
Suh et al., Toxicol Appl Pharmacol 2002 (Lymphoma) : Electrophoretic mobility shift assays and chloramphenicol acetyl transferase reporter gene experiments demonstrated that lipopolysaccharide (LPS) induced DNA binding and transcriptional activity of AP-1 was markedly inhibited by TCDD at 24, 48, and 72 h after cellular activation of CH12.LX cells ... Concordant with this result, TCDD did not inhibit LPS induced AP-1 activity in BCL-1 B cells
Tsi et al., Mol Pharmacol 2002 : ATA not only inhibited nuclear factor-kappaB (NF-kappaB) activation through impairment of the targeting and degradation of IkappaBs but also reduced LPS induced activator protein-1 (AP-1) activation
Hidding et al., Biochem Pharmacol 2002 : Following LPS and other stimuli such as thrombin ( 10-50 unit/mL ), the activation of JNKs went along with the N-terminal phosphorylation of c-Jun which persisted for at least 8 hr. Indirect inhibition of JNK by CEP-11004 ( 0.5-2 microM ), an inhibitor of mixed-lineage kinases (MLK), reduced the LPS induced phosphorylation of both, JNK and c-Jun , by around 50 %, and attentuated the LPS induced the alterations in microglial morphology
Chano et al., Eur J Immunol 2002 : Electrophoretic mobility shift assays and luciferase reporter constructs revealed that LPS induced AP-1 transcriptional activity was normal in DN PKC-alpha overexpressing RAW 264.7 cells
Pinteaux et al., J Neurochem 2002 : Bacterial lipopolysaccharide (LPS) caused increased expression of IL-1RI, IL-1RII and IL-1RAcP mRNAs, induced the release of IL-1beta, IL-6 and prostaglandin-E2 ( PGE2 ), and activated nuclear factor kappaB (NF-kappaB) and the mitogen activated protein kinases ( MAPKs ) p38, and extracellular signal regulated protein kinase ( ERK1/2 ), but not c-Jun N-terminal kinase (JNK) in microglial cultures
Ferlito et al., J Endotoxin Res 2002 : Pretreatment of THP-1 cells with PTx attenuated LPS induced activation of c-Jun-N-terminal kinase (JNK) and p38 kinase, and production of tumor necrosis factor-alpha (TN-alpha) and thromboxane B2 ( TXB2 )
Paik et al., Hepatology 2003 (Liver Cirrhosis) : LPS also activates c-Jun N-terminal kinase (JNK) , as assessed by in vitro kinase assays
MacKenzie et al., Br J Pharmacol 2003 (MAP Kinase Signaling System) : 2. In addition, PDTC potentiated LPS stimulated c-Jun N-terminal kinase (JNK) , p38 mitogen activated protein kinase ( MAP kinase ) and MAP kinase activated protein kinase-2 activity ( the downstream target of p38 MAP kinase )
Cuschieri et al., Shock 2003 (MAP Kinase Signaling System...) : LPS stimulation led to mitogen activated protein kinase activation and translocation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB
Lenert et al., Antisense Nucleic Acid Drug Dev 2003 : In a cell line transfected with an AP-1-beta-galactosidase reporter construct, CpG ODN induced AP-1 transcriptional activity was prevented by inhibitory ODN, but lipopolysaccharide (LPS) induced AP-1 activity was not
Napolitani et al., Eur J Immunol 2003 : Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation
Kang et al., Biochem Biophys Res Commun 2004 : Additionally, specific inhibitors of SAPK/JNK and p38 MAP kinase, SP600125 and SB203580, also suppressed LPS induced increase in IL-1beta gene expression and AP-1 DNA binding
Kang et al., J Pharmacol Sci 2004 : Furthermore, curcumin markedly inhibited LPS induced nuclear factor kappaB (NF-kappaB) and activator protein 1 (AP-1) DNA bindings
Cuschieri et al., Cell Immunol 2004 : Subsequently, LPS induced the degradation of IkappaB, and the nuclear activation of NF-kappaB and AP-1 ... Proteasome inhibition, also, led to increased LPS induced AP-1 activation, and attenuated LPS induced IkappaB degradation resulting in abolished NF-kappaB activation
Krappmann et al., Mol Cell Biol 2004 : Intriguingly, the induction of AP-1 activity by LPS in precursor B cells and primary dendritic cells fully depends on the IKK/NF-kappaB pathway, which promotes expression of several AP-1 family members, including JunB, JunD, and B-ATF ... Thus, our data illustrate that NF-kappaB orchestrates immediate-early effects of LPS signaling and controls secondary AP-1 activation to mount an appropriate biological response
Chambers et al., Clin Exp Immunol 2004 (HIV Infections) : HIV infection of THP-1 myeloid cells resulted in decreased LPS induced nuclear factor binding to the NF-kappaB, AP-1 , and Sp1 sites of the IL-12 p40 promoter
Li et al., Zhonghua Shao Shang Za Zhi 2004 (Acute Lung Injury) : To investigate the changes in plasma level of interleukin-13 (IL-13) and the changes in the pulmonary IL-13 mRNA content and the pulmonary activator protein-1 (AP-1) activity of the rats inflicted with acute lung injury ( ALI ) induced by lipopolysaccharide (LPS) , so as to explore the relationship between IL-13 expression and AP-1 activity
Cuschieri et al., J Surg Res 2004 : Subsequently, LPS induced the activation of NF-kappaB and AP-1
Wu et al., Mol Cell Biol 2004 : Inhibition of SPK by the pharmacological inhibitor N, N-dimethylsphingosine ( DMS ) or SPK1-specific siRNA blocked LPS stimulation of extracellular signal regulated kinase 1/2 and p38 but enhanced LPS induced c-Jun N-terminal kinase activation
Laan et al., J Immunol 2004 : In addition, the activity of LPS induced transcription factor AP-1 , but not NF-kappaB, was down-regulated by CSE
Zhao et al., J Nutr Biochem 2005 : In addition, EPA pretreatment decreased LPS induced c-Jun phosphorylation and c-Jun N-terminal kinase (JNK) activation
Pandey et al., Int Immunopharmacol 2005 : B. diffusa hexane, chloroform and ethanol extracts, and two pure compounds Bd-I ( eupalitin-3-O-beta-D-galactopyranoside ) and Bd-II ( eupalitin ) were evaluated in vitro for their effect on T cell mitogen ( phytohemagglutinin ; PHA ) stimulated proliferation of human peripheral blood mononuclear cell ( PBMC ), mixed lymphocyte culture, lipopolysaccharide (LPS) stimulated nitric oxide production by RAW 264.7, PHA and LPS induced IL-2 and TNF-alpha production, in human PBMCs, superoxide production in neutrophils, human natural killer ( NK ) cell cytotoxicity and nuclear translocation of nuclear factor- ( kappa ) B and AP-1 in PHA stimulated PBMCs
Waetzig et al., Glia 2005 (Encephalitis...) : Stimulation with LPS increased the total amount of nuclear JNKs and the phosphorylation of the transcription factor c-Jun ... The function of JNKs in LPS triggered cellular reactions was investigated using SP600125 ( 0.5-5 microM ), a direct inhibitor of JNKs. Inhibition of JNKs reduced the LPS induced metabolic activity and induction of the AP-1 target genes cyclooxygenase-2 (Cox-2), TNF-alpha, monocyte chemoattractant protein-1 ( MCP-1 ), and interleukin-6 (IL-6) in response to LPS , while ERK1/2 and p38 alpha had a more pronounced effect on LPS induced cellular enlargement than JNKs
Stollenwerk et al., Atherosclerosis 2005 (Arteriosclerosis...) : VLDL did not activate transcription factors NF-kappaB and PPAR-gamma, but it activated AP-1 at least as potently as LPS, and potentiated LPS induced activation of AP-1
Mishra et al., J Biol Chem 2005 (Calcium Signaling) : We previously demonstrated that the c-Jun N-terminal kinase (JNK) , a mitogen activated protein kinase ( MAPK ), differentially regulated LPS- but not TNF-alpha induced CD44 expression in monocytic cells
Suuronen et al., Inflamm Res 2005 (Inflammation) : We also observed that the raloxifene induced protection in N9 microglia was connected to a decline of LPS induced DNA binding activity of AP-1 but not that of NF-kappaB transcription factors
Rak Min et al., Life Sci 2005 : As a mechanism of the anti-inflammatory action shown by CP compound, suppression of LPS induced activation of both nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) has been documented ... Finally, CP compound could provide an invaluable tool to investigate LPS induced NF-kappaB and AP-1 activation, in addition to its therapeutic potential in NO- and IL-6 associated inflammatory diseases
Sasaki et al., Am J Physiol Regul Integr Comp Physiol 2005 (Dehydration...) : Both hepatic and splenic AP-1 expressions were enhanced by LPS
Yamada et al., J Urol 2005 (Urinary Bladder Neoplasms) : Although LPS and IFN-gamma alone marginally activated nuclear factor (NF)-kappaB but not AP-1, LPS plus IFN-gamma augmented NF-kappaB and AP-1
Uto et al., Biochem Pharmacol 2005 : 6-MITC suppressed LPS induced c-Jun phosphorylation, but did not inhibit IkappaB-alpha degradation
Chen et al., Eur J Pharmacol 2005 : LPS induced IkappaB kinase (IKK), nuclear factor-kappaB (NF-kappaB) and activating protein-1 (AP-1) activation , and IFN-gamma induced NF-kappaB, signal transducer and activator of transcription-1 ( STAT1 ) and interferon regulatory factor-1 (IRF-1) activation were reduced by quercetin
Sheu et al., Food Chem Toxicol 2006 (Glomerulonephritis) : Electrophoretic mobility shift assay experiments demonstrated that CLA ( 100 microM ) dramatically reduced activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and cAMP response element binding protein ( CREB ) induced by LPS/IFN-gamma
Wang et al., Am J Respir Cell Mol Biol 2006 (Inflammation) : LPS induced activation of NF-kappaB and AP-1 determined by electrophoretic mobility shift assay were significantly reduced by overexpressing caveolin-1 in RAW264.7 cells
Lendemans et al., J Endotoxin Res 2006 : LPS induced AP-1 binding to DNA was also enhanced in GM-CSF-pre incubated cells ... It is concluded that a tyrosine kinase of the GM-CSF triggered ERK1/2 pathway augments the LPS induced NF-kappaB and AP-1 activation
Lahti et al., BMC pharmacology 2006 : Treatment with SB220025 increased also LPS induced c-Jun N-terminal kinase (JNK) activity
Wang et al., J Biol Chem 2006 : Ablation of jnk2 did not inhibit GalN/LPS induced c-Jun kinase activity, although activity was completely blocked in jnk1-/- mice
Bae et al., Planta Med 2006 : Electrophoretic mobility shift assays revealed that ginsenoside Rh2 significantly inhibited the LPS/IFN-gamma induced AP-1 DNA binding activity, while it enhanced the protein binding to CRE sequences
Jin et al., Planta Med 2006 : Polyozellin suppressed the activation of both LPS induced NF-kappaB and the stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , but had no effect on the extracellular signal regulated kinase ( ERK ) or p38
Patel et al., Biochem Biophys Res Commun 2006 : LPS stimulated both AP-1 ( c-Fos, c-Jun ) and NF-kappaB ( p50 and p65 ) activation, but only inhibition of AP-1 attenuated LPS induced CXCR6 expression ... Using dominant negative expression vectors and siRNA interference, we demonstrate that LPS induces AP-1 activation via MyD88, TRAF6, ERK1/2, and JNK signaling pathways
Hirasawa et al., Life Sci 2006 : The JNK inhibitor SP600125 ( 3-30 microM ) suppressed the LPS induced phosphorylation of c-Jun , and inhibited the LPS induced production of histamine and expression of the HDC mRNA and 74-kDa protein in a concentration dependent manner
Liedtke et al., J Hepatol 2006 : Ablation of jnk2 did not inhibit GalN/LPS induced c-Jun kinase activity, although activity was completely blocked in jnk1-/- mice
Uto et al., Oncol Rep 2007 : LPS induced activation of all of these factors and 6-MITC suppressed LPS induced activation of AP-1 , C/EBPdelta, CREB, but not NF-kappaB
Ramana et al., Cytokine 2006 : The LPS induced DNA binding activity of NF-kappaB and AP1 were significantly inhibited by AR inhibitors, and this effect was mediated through the inhibition of phosphorylation of IkappaB-alpha, IKK alpha/beta and PKC
Lin et al., Biochem Pharmacol 2007 : LPS induced activator protein-1 (AP-1) DNA binding, AP-1 dependent reporter gene activity and c-Jun nuclear translocation were all markedly inhibited by CYL-4d with similar efficacy, whereas CYL-4d produced a weak inhibition of nuclear factor-kappaB (NF-kappaB) DNA binding, NF-kappaB dependent reporter gene activity and p65 nuclear translocation without affecting inhibitory factor-kappa B alpha ( I kappa B alpha ) degradation
Pokharel et al., Biol Pharm Bull 2007 : The lignan suppressed the reporter gene activity and the LPS induced reporter activations of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) were also significantly blocked by 4-hydroxykobusin
Gafencu et al., J Biol Chem 2007 (Inflammation) : In addition to NF-kappaB activation, LPS also activated c-Jun via its phosphorylation by JNK
Luyendyk et al., Arterioscler Thromb Vasc Biol 2007 : These compounds also reduced LPS induction of nuclear AP-1 and expression of Egr-1 without affecting nuclear translocation of NF-kappaB
Huang et al., Int Immunopharmacol 2007 : Activation of JNKs ( not ERKs ) via phosphorylation induction, and an increase in c-Jun ( not c-Fos ) protein expression were involved in LPS- and LTA treated RAW264.7 cells, and those events were blocked by Wog, but not N-Wog, addition
Liu et al., J Ethnopharmacol 2007 (Edema...) : To clarify the mechanisms involved, methanol extracts from fruiting body were found to inhibit the phosphorylation of extracellular signal regulated protein kinases ( ERK ), c-Jun NH2-terminal protein kinases (JNK) and signal transducer and activator of transcription-1 ( STAT-1 ) induced by LPS/IFN-gamma
Muroi et al., Glycobiology 2007 : Among the LPS induced signaling pathways that induce production of TNF-alpha, the activation of c-Jun N-terminal kinase (JNK) was greatly enhanced by LPS and C-Man-WSPW, and the production of TNF-alpha was suppressed by an inhibitor for JNK
El Gazzar et al., Inflamm Res 2007 : Chromatin immunoprecipitation revealed that GATA, AP-1 and NF-AT binding to IL-5 promoter was induced by LPS stimulation and that TQ inhibited GATA binding at the IL-5 promoter but did not affect AP-1 and NF-AT binding
Smolinska et al., Mol Immunol 2008 : In contrast, PP2 did inhibit AP-1 nuclear accumulation in response to LPS
Chen et al., Life Sci 2007 (Inflammation) : In addition, luteolin significantly inhibited the LPS induced DNA binding activity of activating protein-1 (AP-1)
Cho et al., J Nutr 2008 (Inflammation) : Furthermore, DIM decreased LPS induced transcriptional activity of activator protein (AP)-1, AP-1 DNA binding activity, and phosphorylation of stress activated protein kinase/Jun-N-terminal kinase and c-Jun
Tanaka et al., Neurosci Lett 2008 : In primary glial cultures, LPS increased the phosphorylation levels of c-Jun amino-terminal kinase 1 (JNK1) and p38 mitogen activated protein kinase ( MAPK ) ; in primary microglial cultures, it enhanced phosphorylation of extracellular signal regulated kinase ( Erk )
Miyoshi et al., Eur J Neurosci 2008 : ANG II application enhanced the LPS induced increases in IL-1 and nitrite concentrations, as well as the LPS induced morphological changes and AP-1 activation, and these enhancements were inhibited by losartan ( 10 ( -5 ) M )
Wu et al., Toxicol Appl Pharmacol 2008 (Translocation, Genetic) : LPS stimulated phosphorylation of c-Jun N-terminal kinase and translocation of c-Jun and c-Fos from the cytoplasm to nuclei ... However, administration of ketamine significantly decreased LPS induced activation of c-Jun N-terminal kinase and translocation of c-Jun and c-Fos ... Administration of ketamine significantly ameliorated LPS induced DNA binding activity of activator protein-1
Ortiz-Lazareno et al., Immunology 2008 : Proteasome inhibition also led to an increase in LPS+PMA induced AP-1 activation and the attenuation of LPS+PMA induced IkappaB degradation, resulting in the abolition of NF-kappaB activation
Iwasaki et al., Endocr J 2008 : LPS also stimulated the expression of c-Fos gene and protein, and AP1- , but not NF-kappaB-, mediated transcription
Kang et al., Phytother Res 2008 (Edema) : Further study demonstrated that LPS induced DNA binding of AP-1 and phosphorylation of c-jun N-terminal kinase ( JNK ) were inhibited by MK treatment in RAW 264.7 cells, whereas phosphorylation of p38 mitogen activated protein kinase was unaffected
Chen et al., Eur J Pharmacol 2008 (MAP Kinase Signaling System) : Further investigation of the mechanisms revealed that 8-prenylkaempferol inhibited LPS induced c-Jun phosphorylation ( a major component of activator protein-1, AP-1 ), but did not attenuate IkB-alpha degradation nor NF-kappaB nuclear translocation ... On the other hand, LPS induced c-Jun phosphorylation was attenuated in the presence of SP600125
Sundararaj et al., J Leukoc Biol 2008 : Moreover, we showed that simvastatin inhibited LPS stimulated nuclear AP-1 , but not NF-kappaB activity, and the inhibition was reversed by addition of GGPP
Yoshizawa et al., J Immunol 2008 (Arthritis, Rheumatoid) : siRNA knockdown studies showed that TNF, PGN, and LPS induced JNK and c-Jun phosphorylation are MKK7 dependent, while poly ( I-C ) responses require both MKK4 and MKK7
Cho et al., Am J Physiol Endocrinol Metab 2008 (Body Weight...) : In C57BL/6 mice, compound A reduced LPS mediated increases in both plasma cytokine levels and phosphorylated c-Jun in adipose tissue
Cho et al., Mol Endocrinol 2009 : Activated GR inhibited LPS induced activator protein 1 activity, which in turn decreased activating transcription factor 2/c-Jun phosphorylation
Pang et al., Acta Pharmacol Sin 2009 (Inflammation...) : The LPS induced increase in the DNA binding activity of NF-kappaB and activator protein 1 (AP-1) , the nuclear translocation of NF-kappaB p65, the degradation of the inhibitory kappaBalpha protein ( IkappaBalpha ) and the phosphorylation of IkappaBalpha, IkappaB kinase (IKK) alpha/beta, c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs were all suppressed by FLZ
Bumrungpert et al., J Nutr 2009 (Inflammation...) : alpha- and gamma-MG also attenuated LPS activation of c-Jun and activator protein (AP)-1 activity
Park et al., Phytother Res 2010 : Further study demonstrated that glabridin inhibited LPS induced DNA binding activity of NF-kappaB and AP-1 in BV-2 cells
Wu et al., Br J Pharmacol 2009 : Effects of tripterine were investigated on endothelial barrier function, inducible nitric oxide synthase (iNOS) expression, nicotinamide adenine dinucleotide phasphate ( NADPH ) oxidase activity, 3-nitrotyrosine formation, protein phosphatase type 2A (PP2A) activity, activation of extracellular regulated kinase (ERK), c-Jun terminal kinase (JNK) and Janus kinase ( Jak2 ), and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma
Murakami et al., Anticancer Res 2009 : We also investigated tThe inhibitory effects of these compounds on lipopolysaccharide (LPS) stimulated cyclooxygenase-2 (COX-2) mRNA and protein expression and on binding of activator-protein-1 (AP-1) and nuclear factor kappa-B (NF-kappaB) to their respective consensus sequences were also investigated in RAW 264.7 cells ... 2,2'-Biphenol, but not 4,4'-biphenol, showed inhibitory effects on LPS stimulated COX-2 expression and on AP-1 and NF-kappaB binding to their consensus sequences at 1-10 muM
Folco et al., J Biol Chem 2009 (Inflammation...) : We demonstrate that pretreatment of these cells with adiponectin inhibits phosphorylation of nuclear factor kappaB inhibitor ( IkappaB ), c-Jun N-terminal kinase (JNK) , and p38 mitogen activated protein kinase ( MAPK ), induced by either lipopolysaccharide (LPS) or tumor necrosis factor (TNF) alpha, as well as STAT3 phosphorylation induced by interleukin-6 (IL6)
Chuang et al., Toxicol Lett 2009 : LPS selectively enhanced translocation of transcription factor c-Jun from the cytoplasm to nuclei, but not nuclear factor kappa-B ... In parallel, the DNA binding activity of AP-1 was increased by LPS ... Taken together, this study has shown that LPS selectively induces SP-A gene expression possibly through TLR2 mediated activation of c-Jun in human alveolar epithelial A549 cells
Weng et al., J Biomed Sci 2009 (Liver Cirrhosis, Biliary...) : In vitro, Arm ( 1-10 microM ) concentration-dependently attenuated TNF-alpha- and LPS stimulated alpha-SMA protein expression and AP-1 activation by HSC-T6 cells without adverse cytotoxicity
Yadav et al., J Immunol 2009 (Asthma) : We observed that pharmacological inhibition or genetic ablation of AR by small interfering RNA prevented TNF-alpha- as well as LPS induced apoptosis ; reactive oxygen species generation ; synthesis of inflammatory markers IL-6, IL-8, and PGE ( 2 ) ; and activation of NF-kappaB and AP-1 in small airway epithelial cells
Cha et al., Immunol Invest 2009 (Inflammation) : In addition, the essential oil suppressed the LPS stimulated activation of mitogen activated protein kinases ( MAPKs ) as well as the AP-1 DNA binding activity
Chang et al., Inflammation 2010 (Inflammation) : Moreover, LPS induced nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) nuclear protein-DNA binding affinity and reporter gene activity were significantly decreased by LA and GLA
Brandenburg et al., Inflamm Res 2010 (Inflammation) : SF inhibits LPS stimulated ERK1/2 and JNK phosphorylation and thereby inhibits the LPS induced activation of NF-kappaB- and activator protein-1 (AP-1)
Overman et al., Int J Obes Relat Metab Disord 2010 (Inflammation...) : We investigated the effect of GPE pretreatment on LPS mediated activation of mitogen activated protein kinases ( MAPKs ), nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1) , and induction of inflammatory genes in human MPhis ( that is, differentiated U937 cells ) ... Grape powder extract also attenuated LPS activation of MAPKs, NF-kappaB and AP-1 ( c-Jun ), as evidenced by decreased ( 1 ) phosphorylation of c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 ; ( 2 ) degradation of IkappaBalpha and activation of an NF-kappaB reporter construct ; and ( 3 ) phosphorylation of c-Jun and Elk-1
Hwang et al., Int Immunopharmacol 2010 : DSHP-U suppressed LPS induced NO production and iNOS expression at a concentration of 50 microM and inhibited LPS induced phosphorylation of extracellular signal regulated kinase ( ERK ), c-Jun N-terminal kinase (JNK) , and p38 kinase
Lee et al., Eur J Pharmacol 2010 (MAP Kinase Signaling System) : Moreover, eupatolide significantly suppressed the LPS induced expression of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) reporter genes
Yoshioka et al., J Pharmacol Sci 2010 : Furthermore, the effects of LPS on iNOS and NO production were inhibited by the c-Jun N-terminal kinase (JNK) inhibitor SP600125, and LPS induced phosphorylation of JNK and c-Jun was inhibited by NOC18 and DBcGMP
Wiesner et al., Circ Res 2010 (Atherosclerosis...) : In a nuclear factor-DNA binding assay, the cooperative effect of mmLDL and LPS costimulation on c-Jun and c-Fos DNA binding, but not on p65 or p50, was dependent on mmLDL induced activation of extracellular signal regulated kinase ( ERK ) 1/2
Jung et al., Int Immunopharmacol 2010 : Inhibition of these inflammatory mediators appears to be at the transcriptional level, since diosgenin decreased LPS/IFN-gamma induced NF-kappaB and AP-1 activity
Lu et al., Journal of neuroinflammation 2010 (Inflammation) : Resveratrol inhibited LPS induced NF-kappaB activation in both cell types, but inhibited AP-1 activation only in microglia
Li et al., Phytochemistry 2010 : Compounds 1, 5-7, 9-10, and 13 showed anti-inflammatory potency to suppress expression of NF-?B and AP-1 targeted genes including TNF-a and IL-6 induced by lipopolysaccharide (LPS) in mouse macrophages Raw 264.7 cells
Chiou et al., Biochem Pharmacol 2011 : In conclusion, TH-4-PX inhibited LPS induced NF-?B and AP-1 activations by interfering with the posttranslational modification ( phosphorylation and/or ubiquitinylation ) of IRAK-1 in the cell membrane to impede TAK1 mediated activation of IKK and MAPKs signal transduction
Jedinak et al., Nutrition journal 2011 (Inflammation) : OMC also inhibited LPS dependent DNA binding activity of AP-1 and NF-?B in RAW264.7 cells
Zhang et al., Inflamm Res 2011 (Inflammation) : Meanwhile, the activation of p38 MAPK and c-Jun N-terminal kinases (JNK) induced by LPS were decreased by MHNA
Wu et al., Biochem Biophys Res Commun 2011 (Inflammation) : Further, we analyzed the effect of LPS on the DNA binding activity of NF-?B, C/EBP and AP-1 transcription factors in liver and lung from WT and AhR ( -/- ) mice
Vaz et al., Am J Respir Cell Mol Biol 2012 (Acute Lung Injury...) : LPS induced mortality, lung injury, inflammation, cytokine measurements, and AP-1 and NF-?B activities were then assessed in these mice
Tsai et al., J Investig Med 2011 (Inflammation...) : Its suppressive effect on TNF-a, I-309, and IP-10 may, at least in part, involve the down-regulation of LPS induced MKK4-JNK-c-Jun expression
Küper et al., American journal of physiology. Renal physiology 2012 : Inhibition of p38 or ERK1/2 had no significant effect on LPS induced NF-?B activation, nor on activator protein 1- , cAMP response element-, or serum response element-driven reporter constructs
Albanito et al., Glia 2011 : Bergmann glia derived cells expressed toll-like receptor 4 and treatment with bacterial lipopolysaccharide (LPS) induced c-Jun phosphorylation at serine 63, a hallmark of c-Jun transactivation, exclusively in BG cells ... Moreover, LPS induced IL-1ß expression and inhibition of c-Jun N-terminal kinase (JNK) activity abolished both c-Jun phosphorylation and the increase of IL-1ß mRNA
Krifka et al., Biomaterials 2012 : LPS induced expression of activated transcription factors c-Jun , ATF-2, ATF-3 and phospho-Elk1 was decreased in cells co-treated with TEGDMA
Finney et al., Intensive Care Med 2012 : LPS and LTA activated NF-?B and AP-1 in J774 cells
Jin et al., Clin Immunol 2012 : Furthermore, our studies showed that while LPS activated AP-1 and NF?B in U937 cells, it only activated NF?B in fibroblasts
Liu et al., Chinese medicine 2012 : This study demonstrates that a-MG attenuates LPS mediated activation of MAPK, STAT1, c-Fos, c-Jun and EIK-1, inhibiting TNF-a and IL-4 production in U937 cells
Byun et al., Biochem Biophys Res Commun 2012 (Inflammation) : In addition, EGCG treated DCs inhibited lipopolysaccharide (LPS) induced production of pro-inflammatory cytokines ( tumor necrosis factor [TNF ] -a, interleukin [ IL]-1ß, and IL-6 ) and activation of mitogen activated protein kinases ( MAPKs ), e.g., extracellular signal regulated kinase 1/2 ( ERK1/2 ), p38, c-Jun N-terminal kinase (JNK) , and nuclear factor ?B ( NF-?B ) p65 translocation through 67LR
Bang et al., J Ethnopharmacol 2012 (MAP Kinase Signaling System) : Furthermore, AJ suppressed LPS induced NF-?B activation , degradation of I?B-a, phosphorylation of extracellular signal regulated kinase ( ERK ), c-Jun N-terminal kinase (JNK) and p38
Kwon et al., Eur J Pharmacol 2012 (Inflammation) : LPS induced expression levels of JunB, c-Jun and c-Fos were also decreased by BCA treatment ... Moreover, the LPS induced DNA binding activity of AP-1 was markedly inhibited by BCA
Khan et al., J Ethnopharmacol 2013 (Edema...) : Capillarisin also exhibited a promising inhibitory effect on the LPS induced NF-?B and AP-1 DNA binding activity based on an electrophoretic mobility shift assay
Wang et al., Experimental biology and medicine (Maywood, N.J.) 2012 (Inflammation) : LPS also activated mitogen acticated protein kinase ( MAPKs ), c-Jun and NF-?B, and pro-inflammatory genes
Frei et al., J Allergy Clin Immunol 2013 (Inflammation) : Histamine suppressed MDDC chemokine and proinflammatory cytokine secretion, nuclear factor ?B and activator protein 1 activation, mitogen activated protein kinase phosphorylation, and TH1 polarization of naive lymphocytes, whereas IL-10 secretion was enhanced in response to LPS and Pam3Cys
Lee et al., J Ethnopharmacol 2013 : HP decreased LPS induced microglial cell death by 24 % and inhibited LPS induced activation of c-Jun N-terminal kinase (JNK) by 23 % and p42/44MAP kinase ( ERK ) by 34 % treatment of LPS
Xu et al., CNS Neurosci Ther 2013 : In addition, according to the study of related signaling pathways, RvD1 attenuated LPS induced microglia NF-?B activation, MAPK phosphorylation, and activator protein-1 transcriptional activity
Zhu et al., Journal of biomedical research 2010 : LPS stimulated JNK/AP-1 activation, which was inhibited by IL-13 in a dose dependent manner
Xue et al., Placenta 2013 : Our study further proved that miR-155* targeted PTEN 3'-untranslated region ( 3'UTR ) increased IRAKM and NKIRAS1 expression by competing for miR-155* binding, thereby suppressing AP-1/NF-?B activation induced by LPS
Kwon et al., Food Chem Toxicol 2013 : Flavokawain A significantly inhibited LPS induced activation of NF-?B and AP-1 signaling pathways
Oh et al., Molecules (Basel, Switzerland) 2013 (Inflammation...) : The extract also had no effect on LPS stimulated p38 MAPK, JNK, and c-Jun phosphorylation, whereas ERK1/2 phosphorylation was strongly inhibited by BOWE
Tran-Thi et al., Hepatology 1995 : The results indicate a direct participation of NF-kappa B in the regulation of TNF-alpha synthesis and a differential effect of LPS on NF-kappa B and AP-1 , respectively
Dokter et al., Blood 1993 : Finally, using electrophoretic mobility shift assays, evidence was obtained that IL-4 inhibits LPS induced expression of AP-1 protein
Pierce et al., J Clin Invest 1996 : These data indicate that, in contrast to most LPS effects, AP-1 , but not nuclear factor-kappaB, mediates LPS induction of collagenase transcription in macrophagelike cells
de Wit et al., Exp Hematol 1996 : Not only was this effect observed at the mRNA level, but activator protein-1 (AP-1) DNA binding capacity was affected as well, A strong reduction was observed in the LPS induced DNA binding activity of AP-1 in the presence of IFN-gamma
Groupp et al., J Biol Chem 1996 : These data suggest that LPS stimulation of THP-1 cells activates binding of c-Jun , Ets, and Egr-1 to the TF promoter and implicates these factors in the transcriptional activation of TF mRNA synthesis
Sanghera et al., J Immunol 1996 : Bacterial LPS stimulation of murine macrophages leads to increased tyrosine phosphorylation and activation of the 42- and 44-kDa mitogen activated protein kinases ( MAPK ) and the activation of stress activated protein kinases ( SAPK ) /c-Jun N-terminal kinase (JNK) and p38, related to the high osmolarity glycerol protein kinase in Saccharomyces cerevisiae ( HOG1 )
Dokter et al., Leukemia 1996 : In electrophoretic mobility shift assays ( EMSAs ) we showed that IL-10 and IL-4 inhibited LPS induced AP-1 binding activity ... Downregulation of LPS induced AP-1 was accompanied, and thus possibly explained, by a reduced expression at mRNA level of the two major components of the AP-1 complex, namely c-fos and c-jun as determined by Northern experiments
Tanaka et al., Biochem Biophys Res Commun 1997 (Astrocytoma) : Transient expression analysis using the chloramphenicol acetyltransferase assay revealed that activation of the IL-8 promoter by LPS was stimulated by BSO and was suppressed by NAC ; likewise LPS induced activation of both NF kappa B and AP-1 was enhanced by BSO and inhibited by NAC
Yao et al., J Biol Chem 1997 : LPS stimulation increased the binding of c-Jun containing complexes
Camhi et al., Am J Respir Cell Mol Biol 1998 : Mutational analysis of the AB1 enhancer and electrophoretic-mobility-shift assays of nuclear extracts from LPS treated cells further demonstrated that the transcription factor activator protein-1 (AP-1) is critical for AB1 mediated HO-1 gene activation by LPS
Sugita et al., Inflammation 1998 : These results indicate that P. gingivalis LPS activates NF-kappa B and AP-1 in both serum dependent and -independent manners, followed by increased IL-8 transcription in neutrophils, and suggested a role for P. gingivalis LPS in IL-8 synthesis by neutrophils in inflamed gingiva and GCF
Greenberg et al., Alcohol 1998 : ETOH does not directly inhibit NFkappaB or AP-1 , in vivo, but rather inhibits LPS induced activation of the MEKK/MAP kinase system and inhibition of inhibitory protein IkappaBalpha required for formation of AP-1 and NFkappaB, respectively
Chen et al., J Biol Chem 1998 : Taken together, these data demonstrate that nucleotides, especially UTP, can potentiate the LPS induced activation of NF-kappaB and AP-1 and of iNOS induction via a CaMK -dependent pathway and suggest that the UTP dependent up-regulation of iNOS may constitute a novel element in the inflammatory process
Hall et al., J Biol Chem 1999 : These data indicate that LPS induction of TF gene expression in monocytic THP-1 cells is regulated by both the transient phosphorylation of Jun-family proteins and the nuclear translocation and transient binding of NFkappaB/Rel proteins
MacKichan et al., J Biol Chem 1999 : We found that while both C2-ceramide and LPS activated c-Jun N-terminal kinase (JNK) , only LPS also activated extracellular signal regulated kinases ( ERKs )