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CALM3 — JAK2
Text-mined interactions from Literome
Garnovskaya et al., Biochemistry 2003
:
Thus, mitogen induced activation of NHE-1 in VSMC is dependent upon elevated intracellular Ca ( 2+ ) and is mediated by the
Jak2 dependent tyrosine phosphorylation of CaM and subsequent increased binding of
CaM to NHE-1, similar to the pathway previously described for the bradykinin B ( 2 ) receptor in inner medullary collecting duct cells of the kidney [ Mukhin, Y. V., et al. ( 2001 ) J. Biol. Chem. 276, 17339-17346 ]
Turner et al., J Pharmacol Exp Ther 2007
:
We propose that NHE-1 is activated through this pathway : 5-HT1A receptor -- > G ( i2 ) alpha and/or G ( i3 ) alpha -- >
Jak2 activation -- > tyrosine phosphorylation of
CaM -- > increased binding of CaM to NHE-1 -- > induction of a conformational change in NHE-1 that unmasks an obscured proton sensing and/or proton transporting region of NHE-1 -- > activation of NHE-1