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KLF4 — PPARG

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: KLF4 — PPARG (colocalization, imaging technique) Zhang et al., Arterioscler Thromb Vasc Biol 2012*
• IRef Biogrid Interaction: KLF4 — PPARG (physical association, affinity chromatography technology) Zhang et al., Arterioscler Thromb Vasc Biol 2012*

Text-mined interactions from Literome

Oishi et al., Cell Metab 2005 : In 3T3-L1 preadipocytes, KLF5 expression was induced at an early stage of differentiation, and this was followed by expression of PPARgamma2
Chen et al., Mol Pharmacol 2005 (Colonic Neoplasms...) : The effect of 15d-PGJ2 on KLF4 expression seems not to involve its nuclear receptor PPARgamma , in that our data show that : 1 ) KLF4 gene promoter does not contain putative PPRE sequence, 2 ) 15d-PGJ2 rapidly activates extracellular signal regulated kinase ( ERK ) and induces KLF4 mRNA expression, 3 ) KLF4 is induced by 15d-PGJ2 but not by rosiglitazone, a synthetic PPARgamma ligand, and 4 ) 15d-PGJ2 is unable to stimulate PPAR dependent promoter activity in the absence of cotransfected PPARgamma
Rageul et al., Int J Cancer 2009 (Colonic Neoplasms) : This indicates that PPARgamma activation induces KLF4 expression, which in turn increases GPA33 expression
Cekanova et al., Eur J Pharmacol 2010 (Colorectal Neoplasms) : MCC-555 induced expression of the transcription factor, KLF-4 was blocked by a PPARgamma specific antagonist GW9662 in PPARgamma dependent manner in HCT-116 cells