Lockyer et al., J Immunol 2007
:
STAT5 is essential for Akt/p70S6 kinase activity during IL-2 induced lymphocyte proliferation
Wofford et al., Blood 2008
:
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5 mediated activation of Akt to support T-cell survival ... These data demonstrate that IL-7 promotes glucose uptake via a novel signaling mechanism in which STAT5 transcriptional activity promotes Akt activation to regulate Glut1 trafficking and glucose uptake that is critical for IL-7 to prevent T-cell death and maintain homeostasis
Chen et al., Breast Cancer Res 2010
:
Akt is required for Stat5 activation and mammary differentiation
Williams et al., Blood 2012
(Leukemia) :
This aberrant localization was associated with increased STAT5 activation but inhibition of both MAPK and AKT phosphorylation