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EPHB2 — MAP3K2

Text-mined interactions from Literome

Schaefer et al., Immunity 1999 (MAP Kinase Signaling System) : Biochemical activation of MEKK2 follows TCR stimulation, and expression of a dominant negative MEKK2 inhibits TCR mediated conjugate stabilization and ERK and p38 MAP kinase phosphorylation
Sun et al., Mol Cell Biol 2003 : Our studies demonstrate that Src kinase activity is required for ERK5 activation in response to EGF, MEKK2 expression is required for ERK5 activation by Src, Lad and MEKK2 association is required for Src activation of ERK5 , and EGF and Src stimulation of ERK5 regulated MEF2 dependent promoter activity requires a functional Lad-MEKK2 signaling complex
Huang et al., Biochem Biophys Res Commun 2003 : Select point mutations in subdomain X impair MEKK2 phosphorylation of the MAP2Ks, MKK7 and MEK5, abolish MEKK2 induced activation of the MAPKs, JNK1 and ERK5 , and diminish MEKK2 dependent activation of an AP-1 reporter gene
Xu et al., J Biol Chem 2004 : Expression of dominant negative mutants of MEKK2 and MEKK3 also blocked activation of ERK5 by WNK1
Kesavan et al., J Cell Physiol 2004 : MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts ... Targeted disruption of MEKK2 expression causes loss of ERK5 and JNK activation in response to FGF-2 in mouse embryonic fibroblasts ( MEFs ) ... Bacterial lipopolysaccharide (LPS) and TNFalpha neither activate ERK5 nor require MEKK2 for JNK activation, demonstrating specificity of MEKK2 in FGF-2 receptor signaling and control of cytokine gene expression
Wang et al., J Biol Chem 2006 : Our data indicate that activation of Rap1 or MEKK2 is sufficient to stimulate ERK5 , whereas inhibition of either Rap1 or MEKK2 attenuates BDNF activation of ERK5
Nakamura et al., Mol Cell Biol 2007 : Quiescent MEKK2 preferentially binds MEK5, and MEKK2 activation results in ERK5 activation
Enzler et al., J Immunol 2009 : After TCR costimulation, MEKK1 predominantly induces JNK1 activation, whereas the related kinase MEKK2 regulates ERK5 activation
Maruyama et al., EMBO J 2010 : Here, we show that MAPK/ERK kinase kinase 2 (MEKK2) , a member of the MAPKKK family, mediated the specific and transient activation of ERK , which was required for the induction of aquaporin 1 (AQP1) and AQP5 gene expression in response to hyperosmotic stress
Yao et al., PloS one 2010 (MAP Kinase Signaling System) : Calcium regulation of EGF induced ERK5 activation : role of Lad1-MEKK2 interaction
Cronan et al., Oncogene 2012 (Breast Neoplasms...) : MEKK2 was required for epidermal growth factor receptor and Her2/Neu activation of ERK5 , with ERK5 being required for metastasis
Hebron et al., Br J Haematol 2013 (Multiple Myeloma...) : In myeloma tumour cells, MAP3K8 acts as mitogen induced MAP3K in mitosis and is required for TNFa mediated ERK activation
Fanger et al., EMBO J 1997 : Kinase-inactive MEKK1, but not MEKK2 , 3 or 4, strongly inhibited EGF stimulated ERK activity