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PARP1 — RAD51

Text-mined interactions from Literome

Schultz et al., Nucleic Acids Res 2003 : In contrast, inhibition or loss of PARP-1 increases spontaneous Rad51 foci formation, confirming a hyper recombination phenotype in these cells
Tam et al., Cancer Lett 2009 (Carcinoma, Hepatocellular...) : RAD001 in combination with cisplatin induced a significant increase in the number of apoptotic cells, downregulated the expression of pro-survival molecules, Bcl-2, survivin and cyclinD1, and increased the cleavage of PARP , compared to RAD001 or cisplatin alone
Hegan et al., Proc Natl Acad Sci U S A 2010 (Colonic Neoplasms) : However, we also report the unexpected finding that disruption of PARP , itself, either via chemical PARP inhibitors or siRNAs targeted to PARP-1, can inhibit HDR by suppressing expression of BRCA1 and RAD51 , key factors in HDR of DNA breaks