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ANG — EGF

Text-mined interactions from Literome

Uemura et al., Nihon rinsho. Japanese journal of clinical medicine 2005 (Prostatic Neoplasms) : Our previous study demonstrated that Angiotensin II (Ang-II) which is well known to be a main peptide of the renin-angiotensin system could activate the cell proliferation of prostate cancer as well as EGF , and an Ang-II receptor blocker(ARB) could inhibit it through the suppression of phosphorylation of MAPK and STAT3
Dewachter et al., Am J Respir Crit Care Med 2006 (Hyperplasia...) : Ang1 added to P-ECs from patients with iPAH increased the production of endothelin-1 (ET-1) and serotonin, but not of platelet derived growth factor-BB or epidermal growth factor , and increased the amount of mRNA encoding tryptophan hydroxylase-1 ( the rate limiting enzyme of serotonin synthesis ), preproET-1, and ET-1 converting enzyme
Akhtar et al., Br J Pharmacol 2012 (Body Weight...) : Here, we investigated whether Ang- ( 1-7 ) can inhibit hyperglycaemia induced EGF receptor transactivation and its classical signalling via ERK1/2 and p38 MAPK in vivo and in vitro ... Streptozotocin induced diabetic rats were chronically treated with Ang- ( 1-7 ) or AG1478, a selective EGF receptor inhibitor , for 4 weeks and mechanistic studies performed in the isolated mesenteric vasculature bed as well as in primary cultures of vascular smooth muscle cells ( VSMCs ) ... These results show for the first time that Ang- ( 1-7 ) inhibits EGF receptor transactivation via a Mas receptor/Src dependent pathway and might represent a novel general mechanism by which Ang- ( 1-7 ) exerts its beneficial effects in many disease states including diabetes induced vascular dysfunction