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CDC42 — ITSN1

Pathways - manually collected, often from reviews:

• NCI Pathway Database EPHB forward signaling: CDC42/GDP complex (CDC42) → Ephrin B/EPHB2/Intersectin/N-WASP complex (EFNB3_EFNB2_EFNB1-EPHB2-ITSN1-WASL) (modification, collaborate)
  Irie et al., Nat Neurosci 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database Regulation of CDC42 activity: CDC42/GDP complex (CDC42) → Intersectin (ITSN1) (modification, collaborate) Kintscher et al., J Mol Biol 2009*
  Evidence: assay
• Reactome Reaction: CDC42 → ITSN1 (indirect_complex)
• Reactome Reaction: CDC42 → ITSN1 (reaction) Reid et al., J Biol Chem 1999, Schmidt et al., Genes Dev 2002, Jaffe et al., Annu Rev Cell Dev Biol 2005, Ramos-Morales et al., Oncogene 1995, Pasteris et al., Cell 1994, Hart et al., J Biol Chem 1994, Hart et al., J Biol Chem 1996, Zheng et al., J Biol Chem 1996, Van Aelst et al., Genes Dev 1997, Ren et al., J Biol Chem 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: ITSN1 — CDC42 Snyder et al., Nat Struct Biol 2002*
• IRef Bind Interaction: ITSN1 — CDC42 Snyder et al., Nat Struct Biol 2002*
• IRef Bind_translation Interaction: ITSN1 — CDC42 (x-ray crystallography) Snyder et al., Nat Struct Biol 2002*
• IRef Bind_translation Interaction: ITSN1 — CDC42 (experimental interaction detection) Snyder et al., Nat Struct Biol 2002*
• IRef Bind_translation Interaction: CDC42 — ITSN1 (x-ray crystallography) Snyder et al., Nat Struct Biol 2002*
• IRef Biogrid Interaction: ITSN1 — CDC42 (physical association, affinity chromatography technology) Hussain et al., Nat Cell Biol 2001*
• IRef Biogrid Interaction: ITSN1 — CDC42 (direct interaction, pull down) Hussain et al., Nat Cell Biol 2001*
• IRef Biogrid Interaction: ITSN1 — CDC42 (association, x-ray crystallography) Snyder et al., Nat Struct Biol 2002*
• IRef Hprd Interaction: ITSN1 — CDC42 (in vitro) Hussain et al., Nat Cell Biol 2001*, Snyder et al., Nat Struct Biol 2002*, Wang et al., J Biol Chem 2005*
• IRef Intact Interaction: CDC42 — ITSN1 (physical association, enzymatic study) Snyder et al., Nat Struct Biol 2002*
• IRef Intact Interaction: CDC42 — ITSN1 (direct interaction, x-ray crystallography) Snyder et al., Nat Struct Biol 2002*
• IRef Ophid Interaction: ITSN1 — CDC42 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: ITSN1 — CDC42 (aggregation, confirmational text mining) Hussain et al., Nat Cell Biol 2001*

Text-mined interactions from Literome

Pruitt et al., Biochim Biophys Acta 2003 : Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling
Smith et al., Biochemistry 2005 : Moreover, Cdc42 ( Y32F ) is exclusively activated by intersectin , while virtually unresponsive to other Cdc42 activating exchange factors in vitro and in vivo