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CTNNB1 — GJA1

Pathways - manually collected, often from reviews:

• BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages: beta-catenin/LEF1 complex (CTNNB1-LEF1) → CONNEXIN 43 (GJA1) (transcription, activates)

Text-mined interactions from Literome

Sharrow et al., Exp Cell Res 2008 : Since beta-catenin is a binding partner of connexin43, when connexin43 is degraded, beta-catenin activation may contribute to a reflexive increase in connexin43 transcription
Du et al., Cell communication & adhesion 2008 : Lithium chloride regulates connexin43 in skeletal myoblasts in vitro : possible involvement in Wnt/beta-catenin signaling
Wang et al., Biol Reprod 2013 (Wnt Signaling Pathway) : We propose that the WNT2/CTNNB1 pathway regulates CX43 expression and GJIC in granulosa cells by modulating CTNNB1 stability and localization in adherens junctions, and that this is essential for FSH stimulation of GJIC