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CTNNB1 — VDR
Text-mined interactions from Literome
Pálmer et al., J Cell Biol 2001
(Adenocarcinoma...) :
Moreover,
VDR activity was
enhanced by ectopic
beta-catenin and reduced by TCF-4
Shah et al., Mol Cell 2006
:
The signaling/oncogenic activity of
beta-catenin can be
repressed by activation of the
vitamin D receptor (VDR) ... We show here that the
effects of
beta-catenin on
VDR activity are due to interaction between the activator function-2 ( AF-2 ) domain of the VDR and C terminus of beta-catenin ... VDR antagonists, which block the VDRE directed activity of the VDR and recruitment of classical coactivators, do allow VDR to interact with beta-catenin, which suggests that these and perhaps other ligands would permit those functions of the
VDR that
involve beta-catenin interaction
Larriba et al., Endocr Relat Cancer 2007
(Colonic Neoplasms) :
1alpha,25-dihydroxyvitamin D ( 3 ) ( 1,25 ( OH ) ( 2 ) D ( 3 ) )
inhibits beta-catenin signalling by inducing its binding to
vitamin D receptor (VDR) and by promoting beta-catenin nuclear export
Pálmer et al., PloS one 2008
(Skin Neoplasms) :
The
VDR is
required for
beta-catenin induced hair follicle formation in adult epidermis, and the vitamin D analog EB1089 synergizes with beta-catenin to stimulate hair differentiation
Pendás-Franco et al., Anticancer Res 2008
(Colonic Neoplasms) :
Previous work has demonstrated that the most active vitamin D metabolite, 1alpha,25-dihydroxyvitamin D3 ( 1,25 ( OH ) 2D3 )
inhibits beta-catenin transcriptional activity by promoting
vitamin D receptor (VDR) binding to beta-catenin and the induction of E-cadherin expression
Egan et al., Mol Carcinog 2010
(Adenomatous Polyposis Coli...) :
The activity of
beta-catenin , commonly dysregulated in human colon cancers, is
inhibited by the
vitamin D receptor (VDR) , and this mechanism is postulated to explain the putative anti-cancer activity of vitamin D metabolites in the colon ... We investigated the effect of a common FokI restriction site polymorphism ( F/f ) in the human VDR gene as well as the
effect of anti-tumorigenic 1,25-dihydroxyvitamin D ( 3 ) ( 1,25D ) and pro-tumorigenic lithocholic acid (LCA)
VDR ligands on
beta-catenin transcriptional activity ... Furthermore, the influence of a major regulatory protein of beta-catenin, the APC tumor suppressor gene, on
VDR dependent inhibition of
beta-catenin activity was examined ... Using Caco-2 colorectal cancer ( CRC ) cells, it was observed that
VDR ligands, 1,25D and LCA, both
suppress beta-catenin transcriptional activity, though 1,25D exhibited significantly greater inhibition ... These results reveal a previously unrecognized
role for
1,25D-VDR in
APC/beta-catenin cross talk