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LPA — MAPK3
Text-mined interactions from Literome
Della Rocca et al., J Biol Chem 1999
:
In Rat 1 fibroblasts,
Erk 1/2 activation via
LPA and thrombin receptors is completely insensitive to both agents
Mattingly et al., Cell Signal 1999
(Calcium Signaling) :
The stimulation of Ras-GRF can be demonstrated in vitro, in an assay using recombinant Ras substrate, and in situ, by a selective increase in the ability of
LPA to
stimulate mitogen activated protein ( MAP ) kinase
Kim et al., J Cell Biochem 2000
(Calcium Signaling) :
LPA stimulated
MAPK signaling was suppressed by the selective EGF receptor inhibitor and in the dominant negative mutant EGF receptor cell line
Sekharam et al., Biochem J 2000
:
Unlike
LPA induced
mitogen activated protein ( MAP ) kinase activation, LPA stimulated H ( 2 ) O ( 2 ) release was independent of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor
Lee et al., Am J Physiol Cell Physiol 2000
(Calcium Signaling) :
LPA and S1P also
stimulated intracellular Ca ( 2+ ) mobilization and mitogen activated protein kinase (
MAPK ) phosphorylation
Panetti et al., Arterioscler Thromb Vasc Biol 2000
:
S1P and
LPA stimulated
extracellular signal regulated kinase 1/2 phosphorylation and enhanced paxillin localization to focal contacts, with no discernible change in the actin cytoskeleton in FBHEs
Fitzgerald et al., Biochem Biophys Res Commun 2000
:
LPA also
induced phosphorylation of
mitogen activated protein kinase ( p42(MAPK) and p44(MAPK) ) in HOFNH30 transfected but not vector transfected RBL-2H3 cells
Zippel et al., Exp Cell Res 2000
(Calcium Signaling) :
Moreover, in NIH 3T3 fibroblasts it potentiates the
effect of
lysophosphatidic acid (LPA) on Ras protein and
MAPK activity
Huang et al., Arch Biochem Biophys 2000
:
In this work, we examined possible interactions between the
effects of EtOH and
LPA on DNA synthesis, cell proliferation, activating phosphorylation of p44/p42 mitogen activated protein kinases (
MAPK ), and p70 S6 kinase (p70 S6K) activity
Ishii et al., Mol Pharmacol 2000
:
Each of the receptors could couple to multiple G-proteins and induced
LPA dependent inositol phosphate production,
mitogen activated protein kinase activation , and arachidonic acid release while inhibiting forskolin induced cAMP accumulation, although the efficacy and potency of LPA varied from receptor to receptor
Derkinderen et al., J Neurochem 2001
:
In contrast,
lysophosphatidic acid (LPA) , a lipid messenger acting on different receptors,
increased both
p38-MAPK and JNK phosphorylation
Mattingly et al., Cell Signal 2001
(MAP Kinase Signaling System...) :
In SKNSH rDOX6 cells, decreased activation and reduced nuclear translocation of
MAPk in
response to EGF, or
lysophosphatidic acid (LPA) , or phorbol 12-myristate 13-acetate ( PMA ), were observed
Yart et al., J Biol Chem 2002
:
We have observed that dominant negative mutants of p110beta, but not of p110gamma, inhibited
MAPK stimulation in
response to
lysophosphatidic acid (LPA)
Grey et al., Endocrinology 2002
:
Specific inhibitors of p42/44
MAPK signaling did not
block LPA- or S1P induced osteoblast survival
Moughal et al., Cell Signal 2004
(MAP Kinase Signaling System) :
Third, the over-expression of recombinant LPA ( 1 ) receptor potentiated
LPA- and NGF dependent
activation of p42/p44
MAPK
Hilal-Dandan et al., J Mol Cell Cardiol 2004
:
LPA inhibits isoproterenol stimulated cyclic AMP accumulation with an IC ( 50 ) approximately 40 nM and
promotes phosphorylation of
ERK-1/2
Gruber et al., J Dent Res 2004
(MAP Kinase Signaling System) :
Effects of
LPA on proliferation, differentiation, and
mitogen activated protein kinase ( MAPK ) signaling of dental pulp fibroblasts ( DPF ) were examined in vitro ...
Involvement of extracellular signal regulated kinase, p38
MAPK , and c-Jun NH ( 2 ) -terminal kinase in
LPA signaling could be demonstrated by use of specific inhibitors and detection of the phosphorylation status of the kinases
Miyamoto et al., Cancer Res 2004
(Ovarian Neoplasms) :
LPA , which is constitutively produced by ovarian cancer cells, induced HB-EGF ectodomain shedding in SKOV3 and RMG-1 cells, resulting in the transactivation of EGFR and the downstream kinase extracellular signal
regulated kinase/mitogen activated protein kinase
Yun et al., Am J Physiol Cell Physiol 2005
(Colonic Neoplasms) :
LPA2 activated Akt and
Erk1/2 in
response to
LPA
Cechin et al., Neurochem Res 2005
(Glioma) :
The
LPA induced phosphorylation of
ERK 1/2 and CREB was blocked by inhibition of PI3K, PKC and MEK, but that of Akt was only inhibited by wortmannin, the PI3K inhibitor
Moughal et al., J Neurochem 2006
:
Ki16425 reduced the
LPA induced activation of p42/p44
mitogen activated protein kinase ( MAPK ), while acting as a weak stimulator of p42/p44 MAPK on its own, properties typical of a protean agonist ... In contrast, the stimulation of PC12 cells with
LPA leads to a predominant G ( i ) alpha2 mediated Trk A-independent activation of p42/p44
MAPK , where Gbetagamma subunits play a diminished role ... In contrast, the stimulation of PC12 cells with
LPA leads to a predominant G ( i ) alpha2 mediated Trk A-independent activation of
p42/p44 MAPK , where Gbetagamma subunits play a diminished role
Brault et al., Am J Physiol Regul Integr Comp Physiol 2007
:
LPA decreased intracellular GSH levels and
induced a p38
MAPK/JNK dependent inducible nitric oxide synthase (NOS) expression
Bermudez et al., Gynecol Oncol 2007
(Ovarian Neoplasms) :
We report that : ( 1 ) both VEGF and LPA upregulate telomerase activity ; ( 2 )
LPA induction of telomerase activity is VEGF dependent ; ( 3 ) VEGF and LPA induction of telomerase activity is
ERK 1/2 dependent ; and ( 4 ) Sp1 binding sites within the proximal 976- to 378-bp regions of the hTERT promoter are essential for VEGF- and LPA induced hTERT promoter activity
Estrella et al., Int J Oncol 2007
(MAP Kinase Signaling System...) :
LPA stimulation of ovarian cancer cells markedly
increased the phosphorylation and activity of p38 (
MAPK ), p42/p44(MAPK), and PI3K
Billon-Denis et al., J Lipid Res 2008
(Leiomyoma...) :
LPA and scPLD
induced extracellular signal regulated kinase ( ERK ( 1/2 ) )
mitogen activated protein kinase activation
Yin et al., Invest Ophthalmol Vis Sci 2009
:
Early, but not late,
ERK1/2 phosphorylation in
response to wounding,
LPA , and ATP was EGFR independent, but sensitive to the inhibitors of calcium influx, protein kinase C and Src kinase
Kalari et al., Am J Physiol Lung Cell Mol Physiol 2009
(MAP Kinase Signaling System) :
Furthermore, downregulation of native AGK by AGK small interfering RNA decreased intracellular LPA levels ( approximately 2-fold ) and attenuated
LPA induced p38
MAPK , JNK, and NF-kappaB activation, tyrosine phosphorylation of EGF-R, and IL-8 secretion
Holmström et al., Exp Cell Res 2010
:
Non-transactivational, dual pathways for
LPA induced
Erk1/2 activation in primary cultures of brown pre-adipocytes ... Therefore, we have here examined whether
LPA , via EGF transactivation, can
activate Erk1/2 in brown pre-adipocytes ... We found that
LPA could
induce Erk1/2 activation ... However, the LPA induced Erk1/2 activation was independent of transactivation of EGF receptors ( or PDGF receptors ) in these cells ( whereas in transformed HIB-1B brown adipocytes, the
LPA induced
Erk1/2 activation indeed proceeded via EGF receptor transactivation ) ... In the brown pre-adipocytes,
LPA instead
induced Erk1/2 activation via two distinct non-transactivational pathways, one G ( i ) -protein dependent, involving PKC and Src activation, the other, a PTX-insensitive pathway, involving PI3K ( but not Akt ) activation ... Earlier studies showing
LPA induced
Erk1/2 activation being fully dependent on RTK transactivation have all been performed in cell lines and transfected cells
Windischhofer et al., Biochimie 2012
(MAP Kinase Signaling System...) :
As LPA may induce cellular reponses in human osteosarcoma, the present study aimed at investigating expression of various LPA receptors,
LPA mediated activation of
MAPK via G-protein coupling, and expression of early response genes in a cellular model for human osteosarcoma ... Using pharmacological inhibitors, we show that
LPA mediated phosphorylation of p42/44
MAPK by LPA receptor engagement is transmitted by G ( ai ) -dependent pathways through the Src family of tyrosine kinases
Hordijk et al., J Biol Chem 1994
:
Furthermore,
LPA , like epidermal growth factor,
causes tyrosine phosphorylation and activation of the p42/p44
mitogen activated protein ( MAP ) kinases , paralleling p21ras activation
Rosskopf et al., Am J Physiol 1998
:
LPA stimulated a strong increase in the specific phosphorylation of the
mitogen activated protein kinase ( immunoblot analysis ) that was prevented by the MEK inhibitor PD-98059
Buist et al., Biochem Biophys Res Commun 1998
(Neuroectodermal Tumors, Primitive, Peripheral) :
Lysophosphatidic acid (LPA) and endothelin-1 (ET-1), two ligands for G-protein coupled receptors ( GPCRs ),
induce activation of mitogen activated protein kinase (
MAPK ) ... Surprisingly,
LPA and ET-1 did not
induce MAPK activation in SK-N-MC neuroepithelioma cells, even though these GPCR ligands evoked a rapid, transient rise in intracellular free Ca2+ concentration in these cells, indicating that SK-N-MC cells express functional LPA- and ET-1-receptors
Mondorf et al., FEBS Lett 1998
:
When protein kinase C ( PKC ) was depleted by long-term incubation with the phorbol 12-O-myristate 13-acetate the
effect of
Lp(a) on
MAPK activation was completely inhibited ... Forskolin, a stimulator of the adenylyl cyclase, and dibutyryl-cAMP reduced the
effect of
Lp(a) on
MAPK phosphorylation and activation