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HIF1A — NFKB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Jung et al., J Biol Chem 2003
:
The ability of MDAs to induce
HIF-1alpha is
dependent upon activation of
NFkappaB , since inhibition of NFkappaB either pharmacologically or by transfection of an NFkappaB super-repressor plasmid abrogated this induction
Zhou et al., Cancer Res 2004
(MAP Kinase Signaling System) :
In tubular LLC-PK ( 1 ) cells, activation of
nuclear factor kappaB (NFkappaB) by TNF-alpha
resulted in
HIF-1alpha protein synthesis as determined by [ ( 35 ) S ] methionine pulse experiments
Walmsley et al., J Exp Med 2005
(Anoxia) :
Hypoxia induced neutrophil survival is mediated by
HIF-1alpha dependent
NF-kappaB activity
Fernandes et al., Exp Eye Res 2006
:
Consequences of an impairment of the UPP include accumulation of
HIF-1alpha and diminished
NF-kappaB activation , which lead to enhanced expression and secretion of pro-angiogenic factors and attenuated expression of MCP-1
Ramanathan et al., Mol Biol Cell 2007
:
HIF-1alpha mRNA levels were increased in LPS treated macrophages in an
NF-kappaB dependent manner ; NECA strongly increased these levels in an A2AR dependent manner
Sun et al., Oncogene 2007
(Prostatic Neoplasms) :
Additionally, overexpression of NF-kappaB partly reversed the ability of wortmannin to inhibit HIF-1alpha dependent transcriptional activity, suggesting that
NF-kappaB contributes to Akt mediated
HIF-1alpha accumulation during hypoxia
Belaiba et al., Mol Biol Cell 2007
(Anoxia) :
In line, expression of the NFkappaB subunits p50 and p65 enhanced HIF-1alpha mRNA levels, whereas blocking of
NFkappaB by an inhibitor of nuclear factor-kappaB
attenuated HIF-1alpha mRNA induction by hypoxia
van Uden et al., Biochem J 2008
:
siRNA ( small interfering RNA ) studies for individual NF-kappaB members revealed differential effects on HIF-1alpha mRNA levels, indicating that
NF-kappaB can
regulate basal
HIF-1alpha expression
Rius et al., Nature 2008
(Anoxia...) :
Using in vitro systems, it was reported that
HIF-1alpha activates
NF-kappaB , that NF-kappaB controls HIF-1alpha transcription and that HIF-1alpha activation may be concurrent with inhibition of NF-kappaB ... Here we show, with the use of mice lacking IKK-beta in different cell types, that NF-kappaB is a critical transcriptional activator of HIF-1alpha and that basal
NF-kappaB activity is
required for
HIF-1alpha protein accumulation under hypoxia in cultured cells and in the liver and brain of hypoxic animals
Görlach et al., Biochem J 2008
:
One important mechanism underlying these responses is the transcriptional
regulation of
HIF-1alpha by the redox-sensitive transcription factor
NF-kappaB ( nuclear factor kappaB ), which binds at a distinct element in the proximal promoter of the HIF-1alpha gene
Diebold et al., Thromb Haemost 2008
:
In line, RacG12V enhanced
HIF-1alpha promoter activity, and this response was
dependent on
nuclear factor-kappaB (NFkappaB) binding to the HIF-1alpha promoter
Liu et al., Shock 2010
:
Furthermore, the inhibition of moscatilin seemed to be dependent on the repression of
HIF-1alpha accumulation and
NF-kappaB activation
Yeligar et al., J Immunol 2009
:
Ethanol mediated activation of
NF-kappaB led to
HIF-1alpha activation and concomitant RANTES expression
Kuphal et al., Eur J Cancer 2010
(Melanoma...) :
Interestingly, the inhibition of the NFkappaB pathway also reduced the accumulation of HIF-1alpha assuming a context between ROS and NFkappaB, and suggesting that ROS and
NFkappaB activity
contribute to
HIF-1alpha accumulation
Trebec-Reynolds et al., J Cell Biochem 2010
:
VEGF-A expression in osteoclasts is regulated by
NF-kappaB induction of
HIF-1alpha ... In turn,
Hif1alpha mRNA levels are
induced by RANKL mediated activation of
NF-kappaB
Rohwer et al., PloS one 2010
(Stomach Neoplasms) :
Furthermore, loss of
HIF-1alpha abrogated, in a p53 dependent manner, chemotherapy
induced DNA binding of
NF-kappaB and expression of anti-apoptotic NF-kappaB target genes