Gene interactions and pathways from curated databases and text-mining

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PTEN — STAT3

Text-mined interactions from Literome

Sun et al., J Gen Virol 2002 (Laryngeal Neoplasms...) : These data indicate that PTEN negatively regulates STAT3 activation in HPV infected papilloma cells
Iliopoulos et al., Mol Cell 2010 (Adenocarcinoma...) : STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer
Ke et al., J Hepatol 2012 (Disease Models, Animal...) : Parallel in vitro studies with bone marrow derived-macrophages have confirmed that HO-1-STAT3 axis induced PI3K/Akt negatively regulated PTEN expression in TLR4 dependent fashion
Jung et al., Oncogene 2013 (Carcinoma, Non-Small-Cell Lung...) : Pharmacological inhibition of phosphatidyl inositol 3-kinase or transfection with wild-type PTEN suppressed phosphorylation of Akt, mTOR and STAT3 ( Y705 ), sphere formation, and CXCR4 expression in A549/GR cells, whereas mutant PTEN enhanced these events
Cai et al., Basic Res Cardiol 2012 (Myocardial Reperfusion Injury) : In the gastrocnemius muscle, RIPC resulted in immediate inactivation of the phosphatase PTEN and activation of Stat3 , with increased IL-10 expression 24 h later