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IL18 — PTX4

Text-mined interactions from Literome

Samardzic et al., Clin Exp Immunol 2001 : The effect of phosphodiesterase inhibiting anti-inflammatory drug pentoxifylline ( PTX ) on LPS induced IL-18 synthesis and IL-18 mediated IFN-gamma-induction were investigated ... In a dose dependent manner PTX inhibited production of IL-18 in LPS treated cultures of murine spleen cells and bone marrow derived macrophages
Schneider et al., Infect Immun 2007 : Stimulation of T cells with holotoxin ( PTx ) or the B subunit alone ( PTxB ) rapidly induces signaling events resulting in inositol phosphate accumulation, Ca ( 2+ ) mobilization, interleukin-2 (IL-2) production, and mitogenic cell growth
Dong et al., J Clin Immunol 1997 : PTX at a 3.5 x 10 ( -5 ) M concentration significantly inhibited T cell proliferation and the production of tumor necrosis factor-alpha, interleukin-2 , and interleukin-4
Schratzberger et al., Immunopharmacology 1999 : In the present study, we investigated the effects of the anti-inflammatory drug pentoxifylline ( PTX ) on activation of endothelial cells for enhanced adhesion and transmigration of neutrophils by lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1) and granulocyte colony stimulating factor ( G-CSF )