◀ Back to PIK3CA
LEP — PIK3CA
Text-mined interactions from Literome
Niswender et al., Diabetes 2003
(Anorexia...) :
These findings support the hypothesis that the IRS-PI3K pathway is a mediator of insulin action in the arcuate nucleus and, combined with recent evidence that
leptin activates
PI3K signaling in the hypothalamus, provide a plausible mechanism for neuronal cross-talk between insulin and leptin signaling
Lee et al., Experimental biology and medicine (Maywood, N.J.) 2003
:
Leptin may
stimulate PI 3-K to constrain PLC-PKC induced insulin secretion from islets of Lep ( ob ) /Lep ( ob ) mice
Niswender et al., J Histochem Cytochem 2003
:
We conclude that immunocytochemical PIP3 staining can detect changes in
PI3K activation
induced by insulin and
leptin in cell culture and intact liver
Solinas et al., FEBS Lett 2004
:
Our results suggest that the direct effect of
leptin in stimulating thermogenesis in skeletal muscle is mediated by substrate cycling between de novo lipogenesis and lipid oxidation, and that this cycle
requires both
PI3K and AMPK signaling
Benomar et al., Biochem J 2005
:
Furthermore,
leptin or insulin pre-treatment
increased basal
PI3K activity and IRS-1 or IRS-2 association with p85 and abolished acute insulin or leptin effect, in addition to the down-regulation of IRS-1 and IRS-2
Xu et al., J Clin Invest 2005
(Synaptic Transmission) :
We developed mice in which a fluorescent reporter for PI3K activity is targeted to either Agrp or POMC neurons and used 2-photon microscopy to measure dynamic
regulation of
PI3K by insulin and
leptin in brain slices
Aquila et al., J Clin Endocrinol Metab 2005
:
In uncapacitated sperm, both insulin and
leptin increased
PI3K activity, Akt S473, and glycogen synthase kinase-3 S9 phosphorylation
Morrison et al., Am J Physiol Endocrinol Metab 2005
:
Because NPY/AgRP neurons project to the hypothalamic paraventricular nucleus ( PVN ), we next investigated whether
leptin activation of PVN neurons is similarly
PI3K dependent ... We conclude that
leptin requires intact
PI3K signaling both to inhibit hypothalamic Npy and Agrp gene expression and activate neurons within the PVN
Morton et al., Cell Metab 2005
(Body Weight) :
These findings suggest that hypothalamic
leptin signaling is an important determinant of glucose metabolism and that the underlying neuronal mechanism
involves PI3K
Zeidan et al., J Pharmacol Exp Ther 2007
(Hypertrophy) :
Our results indicate that the activation of RhoA/ROCK and
PI3K/Akt plays a pivotal role in
leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics
Metlakunta et al., Endocrinology 2008
(Body Weight...) :
Leptin ( ip ) significantly
increased hypothalamic
PI3K activity and phosphorylated signal transducer and activator of transcription 3 ( p-STAT3 ) levels in LFD fed mice but not in DIO mice
Plum et al., Cell Metab 2007
(Thinness) :
Enhanced
leptin stimulated
Pi3k activation in the CNS promotes white adipose tissue transdifferentiation ... These data provide direct genetic evidence that
leptin stimulated
Pi3k signaling in the CNS regulates energy expenditure via activation of SNA to perigonadal WAT leading to BAT-like differentiation of WAT
Rafail et al., Thromb Res 2008
(Inflammation...) :
Inhibition studies revealed that the effect of
leptin on TF expression is
mediated , at least in part, by JAK2 and
PI3K
Hill et al., J Clin Invest 2008
(Body Weight) :
Acute effects of
leptin require
PI3K signaling in hypothalamic proopiomelanocortin neurons in mice ... It has been proposed that
leptin action
requires PI3K activity
Jiang et al., Hepatology 2008
:
We found that
leptin induced the
PI3K dependent activation of Rac1, and that nicotinamide adenine dinucleotide phosphate, reduced form ( NADPH ) oxidase activation was also implicated in this process
Roman et al., Mol Cell Endocrinol 2010
:
Central
leptin action
requires PI3K activity to modulate glucose homeostasis and peripheral metabolism
Uddin et al., Endocr Relat Cancer 2010
(Carcinoma, Papillary...) :
Inhibition of PI3K activity by its inhibitor LY294002 abrogated
leptin mediated
PI3K/AKT signaling
Heldsinger et al., J Biol Chem 2011
(Ion Channel Gating) :
Synergistic interaction between
leptin and cholecystokinin in the rat nodose ganglia is
mediated by
PI3K and STAT3 signaling pathways : implications for leptin as a regulator of short term satiety
Metlakunta et al., Am J Physiol Regul Integr Comp Physiol 2011
(Obesity...) :
In food restricted WT mice with reduced body weight,
leptin increased hypothalamic
PI3K activity only at 30 min, and p-STAT3 levels at 30-120 min postinjection ... In the next experiment with a clonal hypothalamic neuronal cell line expressing proopiomelanocortin, we observed that whereas
leptin significantly
increased IRS1 associated
PI3K activity and p-JAK2 levels in cells transfected with control vector, it failed to do so in SOCS3 overexpressed cells
Williams et al., J Neurosci 2011
:
The acute effects of
leptin require
PI3K signaling in the hypothalamic ventral premammillary nucleus
Xu et al., Hepatogastroenterology 2011
(Fatty Liver) :
Leptin may be involved in NAFLD pathogenesis by activating the PI3-K/Akt kinase pathway via OB-R and the defective
leptin activation of
PI3-K is a novel mechanism of leptin resistance in NAFLD
Warne et al., Cell Metab 2011
(Fatty Liver) :
Impairment of central
leptin mediated
PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity ... Attenuation of
leptin induced
PI3K signaling, brought about by transgenic expression of phosphatase and tensin homolog (PTEN) in leptin receptor neurons, leads to decreased hepatic sympathetic tone and increased triglyceride levels without affecting adiposity or hepatic insulin signaling
Sahu et al., J Neuroendocrinol 2013
:
In the hypothalamus,
leptin stimulates STAT3 activation, and
induces PI3K and PDE3B activities, among others
Pijet et al., Cytokine 2013
(MAP Kinase Signaling System) :
Detailed acute and chronic studies with the use of metabolic inhibitors revealed that both JAK/STAT3 and MEK/MAPK but not
PI3-K/AKT/GSK-3ß signaling pathways were
activated by
leptin , and that STAT3 ( Y ( 705 ) P-STAT3 ) and MEK ( T ( 202/ ) Y ( 204 ) P-ERK1/2 ) mediate these effects