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IL5 — IL6

Text-mined interactions from Literome

Shinoda et al., Cell Signal 1999 : C2-ceramide did not affect the IL-6 synthesis induced by interleukin-1
Albanesi et al., J Invest Dermatol 2000 (Dermatitis, Allergic Contact...) : In addition, interleukin-17 stimulated the release of growth regulated oncogene-alpha, granulocyte-macrophage colony stimulating factor, and interleukin-6 , with synergistic or additive effects when used together with interferon-gamma or interleukin-4
Lee et al., Arch Pharm Res 2000 : High level of macrophage-colony stimulating factor ( M-CSF ) and interleukin (IL)-6 was detected in the TFGD-culture supernatant, whereas granulocyte/macrophage-colony stimulating factor ( GM-CSF ), IL-3, IL-4, IL-5 , IL-13, or interferon (IFN)-gamma was undetectable
Yun et al., Life Sci 2000 (Leukemia, Erythroblastic, Acute...) : Genistin showed inhibitory effects on IL-5 and IL-3 bioactivities, but did not inhibit GM-CSF and IL-6 bioactivities
Suchin et al., J Am Acad Dermatol 2001 (Eosinophilia...) : Increased interleukin 5 production in eosinophilic Sézary syndrome : regulation by interferon alfa and interleukin 12
Ishikawa et al., Jpn J Vet Res 2001 : Brain interleukin-1 is involved in blood interleukin-6 response to immobilization stress in rats
Li-Weber et al., Eur J Immunol 2001 : In this study, we have investigated the control mechanisms for IL-5 production and found that ectopic expression of NF-IL6 ( C/EBPbeta ) increases endogenous IL-5 mRNA expression
Andoh et al., Biochim Biophys Acta 2002 : In human pancreatic myofibroblasts, interleukin (IL)-17 markedly enhances tumor necrosis factor (TNF)-alpha induced IL-6 secretion through the induction of IL-6 mRNA stabilization
Heijink et al., Immunology 2002 : This study shows that IL-6 induces up-regulation of IL-4 and IL-5 after short ( 5 min ) preincubation periods in freshly isolated, alpha-CD3/alpha-CD28 stimulated T cells ... Additional experiments indicate that the long-term priming effect of IL-6 on IL-5 production is dependent on IL-2 signalling ... This is not the case for the short-term IL-6 effect on IL-5 secretion, where the p38 mitogen activated protein kinase dependent induction of activator protein-1 DNA binding activity is involved, independent of signal transducer and activator of transcription 3 phosphorylation
Kovár et al., Parasitol Res 2002 : ELISA ( protein level ) and RNAse protection assay ( mRNA level ) showed that SGE enhanced interleukin (IL)-1alpha, IL-1beta, IL-1Ra, IL-6 , and IL-12p40 cytokines, whereas production of IL-2, IL-5 , IL-10, and IL-13 was decreased
Yamamoto et al., Arthritis Rheum 2003 (Arthritis, Experimental...) : The effects of RasDN overexpression on cellular proliferation, interleukin-1 (IL-1) induced activation of mitogen activated protein kinases ( extracellular signal regulated kinase [ ERK ], p38, c-Jun N-terminal kinase [ JNK ] ), and IL-6 production by synovial cells were analyzed
Planck et al., Invest Ophthalmol Vis Sci 1992 : Retinal pigment epithelial cells secrete interleukin-6 in response to interleukin-1
Shimizu et al., Arch Oral Biol 1992 : Stimulation by interleukin-1 of interleukin-6 production by human periodontal ligament cells
Nishitai et al., J Biol Chem 2004 : Instead, interleukin-1 beta (IL-1 beta) induced IL-6 gene expression was greatly suppressed in sek1 ( -/- ) mkk7 ( -/- ) fibroblasts
Saito et al., Mech Ageing Dev 2003 (Endotoxemia...) : The stress mediated induction of interleukin-1beta, interleukin-6 , and interleukin-10 ( IL-1beta, IL-6, and IL-10 ) in the circulating blood tended to be higher with aging in both CLP and LPS models, and in particular, the induction of IL-6 was significantly augmented with aging
Singh et al., Environ Health Perspect 2004 (Inflammation) : A-DEPs stimulated an increase in interleukin-6 (IL-6), tumor necrosis factor alpha, macrophage inhibitory protein-2, and the TH2 cytokine IL-5 , whereas SRM 2975 only induced significant levels of IL-6
Silfverswärd et al., J Orthop Res 2004 : Interleukin-4 and interleukin-13 potentiate interleukin-1 induced secretion of interleukin-6 in human osteoblast-like cells
Nesbitt et al., Mol Biol Cell 1992 (Inflammation) : We employed ribonuclease protection assays to measure the expression of IL-6-R and gp130 mRNA in primary rat hepatocytes in response to IL-6, interleukin-1 , dexamethasone, and combinations thereof
Méndez-Dávila et al., J Endocrinol Invest 2004 (Osteoporosis) : We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and interleukin-1 stimulated interleukin (IL)-6 , transforming growth factor-beta1 ( TGF-beta1 ) and insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Hashmi et al., Coron Artery Dis 2006 (Angina, Unstable) : Role of interleukin-17 and interleukin-17 induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease
Kawanishi et al., Immunol Invest 1991 : IL-4, IL-5 and IL-6 alone or in combination do not act as IgA heavy chain switch cofactors, but IL-5 and IL-6 do act at least as B cell terminal differentiation factors for any isotype-specific gut associated lymphoid tissue (GALT) ( mesenteric lymph node ) B cells in the presence or absence of LPS
Szabo et al., J Clin Immunol 1991 (Burns...) : Furthermore, interleukin-4 dependent downregulation of monocyte interleukin-6 expression is confirmed at both the supernatant and the mRNA levels
Galatowicz et al., Clin Exp Allergy 2007 (Conjunctivitis, Allergic...) : For conjunctival biopsy derived cultures ( n=11 ), FcepsilonR1 stimulation increased histamine, TNF-alpha, TNF-beta, IL-5 and IL-8 levels and the production of IL-5, IL-6 ( P < 0.05 ), histamine and IL-8 ( P < 0.01 ) was inhibited by epinastine
Burch et al., Agents Actions 1991 (Wounds and Injuries) : Basal interleukin-1 and 6 release were not affected by sucralfate, but the agent enhanced interleukin-1 stimulated interleukin-6 release from fibroblasts
Krogh Rasmussen et al., Acta Endocrinol (Copenh) 1991 : In conclusion, it is unlikely that interleukin 6 by itself mediates the biological effects of interleukin 1 on human thyroid cells
Layh-Schmitt et al., Curr Opin Rheumatol 2008 (Spondylarthropathies) : In mice, transforming growth factor-beta and interleukin-6 are critical, whereas interleukin-23 is more important at later stages promoting interleukin-17 production
Løbner et al., J Med Food 2008 : The TNF-alpha, IFN-gamma, and IL-6 responses to TT were enhanced after 8 and 14 days ( P < .002-.05 ), while IL-5 responses increased significantly within 3 days ( P < .04 ) and fell below baseline levels after 14 days ( P < .008 )
Baigrie et al., Lymphokine Cytokine Res 1991 (Aortic Aneurysm...) : A sequential interleukin-1 beta and interleukin-6 response has not been noted before in vivo, and would seem to provide evidence supporting the in vitro observation that interleukin-1 induces interleukin-6 synthesis and release
Braquet et al., Int Arch Allergy Appl Immunol 1991 : We compared the effects of platelet activating factor (PAF), interleukin-1 beta (IL-1 beta) and polyriboinositic-polyribocytidylic acid ( poly-I:C ) on IL-6 production by confluent L929 mouse fibroblasts
Zhang et al., Beijing Da Xue Xue Bao 2010 (Chlamydia Infections...) : [ Early production of interleukin-17 in airway upon Chlamydia trachomatis infection increases the local secretion of IL-6 and MIP-2 ]
Kim et al., Naunyn Schmiedebergs Arch Pharmacol 2011 : Grape seed proanthocyanidin extract inhibits interleukin-17 induced interleukin-6 production via MAPK pathway in human pulmonary epithelial cells
Tanabe et al., Journal of neuroinflammation 2011 : Midazolam suppresses interleukin-1ß induced interleukin-6 release from rat glial cells
Nakamura et al., Eur J Oral Sci 2011 (Gingivitis) : Involvement of angiotensin II type 1 receptors in interleukin-1ß induced interleukin-6 production in human gingival fibroblasts
Zhang et al., Mol Cell Biol 1990 (Chromosome Deletion) : Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence
Libert et al., Eur J Immunol 1990 : Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice
Kuroyanagi et al., Biochimie 2013 : ( - ) -Epigallocatechin gallate amplifies interleukin-1 stimulated interleukin-6 synthesis in osteoblast-like MC3T3-E1 cells
Bunning et al., Biochem Biophys Res Commun 1990 : Independent induction of interleukin 6 and prostaglandin E2 by interleukin 1 in human articular chondrocytes
Shalaby et al., Clin Immunol Immunopathol 1989 (Shock, Septic) : Endotoxin, tumor necrosis factor-alpha and interleukin 1 induce interleukin 6 production in vivo
Helle et al., Eur J Immunol 1988 : Interleukin 6 is involved in interleukin 1-induced activities
Swain et al., Proc Natl Acad Sci U S A 1981 : We conclude that the C.C3.11.75 TRF activity is not due to interleukin 1 or to interleukin 2 but to a third factor provisionally designated as ( DL ) TRF
Zimecki et al., Arch Immunol Ther Exp (Warsz) 1994 : Interleukin 6 produced by activated thymocytes induces interleukin 1 production by macrophages
Cadman et al., Neurosci Lett 1994 (Astrocytoma) : cAMP is not involved in interleukin-1 induced interleukin-6 release from human astrocytoma cells
Sakai et al., Rinsho Byori 1994 (Acute Disease...) : IL-6 increased rather rapidly than other acute phase proteins, and increases of CRP, TRF , AAT, AAG, CER, HAP and AMG followed
Carlson et al., J Neurochem 1995 (Astrocytoma) : Prolonged exposure to phorbol ester eliminated subsequent stimulation by phorbol ester but only partially decreased interleukin-1 induced interleukin-6 and had no effect on the activities of selected inhibitors including calphostin C ... We conclude that tyrosine kinase activity is essential for interleukin-1 induced interleukin-6 production in U373 astrocytoma cells and that activity of a phorbol ester-insensitive, atypical protein kinase C isozyme may also be involved
Zitnik et al., Am J Physiol 1993 : cAMP inhibition of interleukin-1 induced interleukin-6 production by human lung fibroblasts
Zaitseva et al., Infect Immun 1995 : Gamma interferon ( IFN-gamma ), interleukin-2 (IL-2), IL-4, and IL-5 induction was assayed by mRNA-specific PCR and by enzyme linked immunosorbent assay and bioassay for protein production
Adams et al., Neurosurgery 1994 (Neuroma, Acoustic) : Tumor necrosis factor-alpha, interleukin-1-beta , and cholera toxin all stimulated IL-6 secretion
Hoffmann et al., J Hepatol 1994 : Furthermore, lipopolysaccharide, tumor necrosis factor-alpha, interferon-gamma, interleukin-1 beta and phorbol ester induced interleukin-6 production and, at the same time, suppressed the level of interleukin-6 receptor mRNA
Judd et al., Am J Physiol 1995 : ZG cells released IL-6 and TNF, and this release was stimulated by lipopolysaccharide, interleukin-1 alpha, interleukin-1 beta, a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Ng et al., J Biol Chem 1994 : Differential induction of the interleukin-6 gene by tumor necrosis factor and interleukin-1
Moutabarrik et al., Scand J Immunol 1994 : IL-6 was detected in the culture supernatants of human GEC and its production was enhanced in time and dose dependent manner by lipopolysaccharide (LPS), interleukin-1 beta (IL-1 beta) and tumour necrosis alpha ( TNF-alpha )
Ueo et al., J Am Coll Surg 1994 : The IL-6 secretion by skin explants was significantly enhanced either by tumor necrosis factor or interleukin-1 , while it was inhibited by corticosteroids
Enokihara et al., Int Arch Allergy Immunol 1994 : In this system, IL-5 production was enhanced by IL-4 and was inhibited by IFN alpha, TGF beta and IL-6
Utsunomiya et al., Eur J Pharmacol 1994 (Pleurisy) : However, production of tumor necrosis factor (TNF) and interleukin-1 in the pleural exudate was significantly enhanced by the pretreatment with indomethacin, whereas the interleukin-6 level was reduced
Levine et al., Psychoneuroendocrinology 1994 : Pituitary-adrenal and interleukin-6 responses to recombinant interleukin-1 in neonatal rats
Boxman et al., J Invest Dermatol 1993 : The remaining interleukin-1 activity, however, was sufficient for maximal induction of interleukin-6 production in fibroblasts
Estes et al., J Immunol 1993 (Cestode Infections) : In addition, the cell lines constitutively produce IL-6 and can be induced to express IL-2, but not IL-4, IL-5 , or IFN-gamma
de Fijter et al., Am J Kidney Dis 1996 : In addition, interleukin-1-beta induced interleukin-6 production by human mesothelial cells was measured in the presence of concentrations of calcium increasing from 0 to 3.0 mmol/L. Fc receptor- mediated uptake of S epidermidis by PMO in the complete absence of Ca++ was comparable to that by PMO incubated in GHBSS with calcium
Topley et al., J Am Soc Nephrol 1996 : Similarly, interleukin (IL)-1 beta induced IL-6 synthesis by HPMC was also only significantly reduced by the pH 5.2 lactate solution
Poulsen et al., Cytokine 1996 (Dermatitis, Atopic...) : The combination ION + PMA induced the highest levels of IL-2, IL-4, IL-5 , IFN-gamma and TNF-alpha, whereas maximal production of IL-6 and TNF-beta were induced by PHA and PHA + PMA, respectively
Bodine et al., Endocrinology 1996 : Finally, interleukin-1 beta and tumor necrosis factor-alpha ( 1-1000 pM ) stimulated dose dependent increases in the secretion of interleukin-6 and monocyte chemoattractant protein-1 at 34 C and 40C
Hedges et al., Cytokine 1996 : IL-4, IL-13, IFN-gamma, and TGF-beta 1, but not IL-2, IL-5 , IL-10 or IL-12, stimulated IL-6 secretion ... IL-5 , IL-12, IL-13 and TGF-beta 1 additively enhanced the bacterially induced IL-6 secretion, but they did not affect IL-8 secretion
Meyer et al., Clin Sci (Lond) 1997 (Endotoxemia...) : 3. Administration of endotoxin induced a greater than fourfold increase in brain interleukin-1 , a greater than threefold increase in interleukin-6 and an increase in mRNA for both cytokines
Jones et al., J Pathol 1997 (Meningioma) : Effect of interleukin-1 and dexamethasone on interleukin-6 production and growth in human meningiomas
Porro et al., J Pharmacol Exp Ther 1998 (Shock, Septic) : In vitro experiments showed that ITF1779 inhibited not only huTNFalpha induced cytotoxicity on LM cells but also another response of the same cells, interleukin-1 induced interleukin-6 production
Kozawa et al., Prostaglandins Leukot Essent Fatty Acids 1998 : However, retinoic acid had little effect on the IL-6 synthesis induced by interleukin-1
Staels et al., Nature 1998 (Coronary Disease...) : In these smooth-muscle cells, we find that PPARalpha ligands, and not PPARgamma ligands, inhibit interleukin-1 induced production of interleukin-6 and prostaglandin and expression of cyclooxygenase-2