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CXCL16 — VEGFA
Text-mined interactions from Literome
Darash-Yahana et al., FASEB J 2004
(Adenocarcinoma...) :
In vitro,
CXCL12 induced the proliferation and
VEGF secretion but not migration of PC3 and 22Rv1 cells overexpressing CXCR4
Hosokawa et al., Clin Exp Immunol 2005
(Periodontal Diseases) :
Moreover,
CXCL12 induced
vascular endothelial growth factor ( VEGF ) production by HGF
Brand et al., Exp Cell Res 2005
(Colorectal Neoplasms...) :
Moreover,
CXCL12 increases
vascular endothelial growth factor ( VEGF ) expression and cell proliferation but has no effect on CRC apoptosis
Yao et al., J Neurooncol 2008
(Disease Models, Animal...) :
In this study, we examined the capacity of FPR to
regulate the production of another angiogenic factor, the chemokine IL-8 (
CXCL8 ), in addition to its demonstrated ability to induce
VEGF secretion by malignant glioma cells
Martin et al., J Biol Chem 2009
:
CXCL8/IL8 stimulates
vascular endothelial growth factor ( VEGF ) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM ( Carma3/Bcl10/Malt1 ) complex ... Furthermore, we identified the components of the CBM complex, Carma3, Bcl10, and Malt1, as key mediators of the
CXCL8/IL8 induced NFkappaB activation and
VEGF up-regulation ... Together, these findings support the existence of an NFkappaB mediated pathway by which the proinflammatory chemokine
CXCL8/IL8 controls the expression of
VEGF in endothelial cells, thereby promoting the activation of VEGF receptors in an autocrine fashion