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ELAVL1 — VEGFA

Text-mined interactions from Literome

Dixon et al., J Clin Invest 2001 (Colonic Neoplasms) : In particular, we found that the RNA-stability factor HuR binds to the COX-2 ARE, and overexpression of HuR , as detected in tumors, results in elevated expression of COX-2, VEGF , and IL-8
Datta et al., Oncogene 2005 (Carcinoma, Renal Cell...) : Role of elongin binding domain of von Hippel Lindau gene product on HuR mediated VPF/VEGF mRNA stability in renal cell carcinoma
Sakuma et al., J Neurooncol 2008 (Brain Edema...) : Furthermore, we investigated the involvement of HuR in the upregulation of VEGF-A expression using primary meningioma cell cultures ... In in vitro experiments, hypoxia induced the upregulation of VEGF-A expression and the cytoplasmic translocation of HuR protein in meningioma cells, and inhibition of the cytoplasmic translocation of HuR reduced the upregulation of VEGF-A expression in meningioma cells ... These findings suggest that the expression of VEGF-A relates to the development of PTBE with meningiomas and the histological grade, and that HuR is involved in the upregulation of VEGF-A expression in human meningiomas
Ido et al., Neuropathology 2008 (Astrocytoma...) : Furthermore, we studied the involvement of HuR in the upregulation of VEGF-A expression using malignant astrocytoma cell lines ... These findings suggest that the expression of VEGF-A and cytoplasmic translocation of HuR relates to the histological grade, and that HuR is involved in the upregulation of VEGF-A expression, in human astrocytic tumors
Basu et al., J Biol Chem 2010 (Kidney Neoplasms) : It is established that the mRNA binding protein HuR may play a critical role in VEGF mRNA stability
Richards et al., Ann Surg 2010 (Adenocarcinoma...) : Finally, HuR binds to VEGF mRNA implying that HuR , in part, regulates VEGF expression in PDA
Amadio et al., Molecular vision 2012 : Direct activation of PKCß induced HuR translocation from the nuclear area to the cytoplasm, and increased the protein levels of the kinase itself, HuR, and VEGF in PC and EC in both culture conditions
Chang et al., J Biol Chem 2013 (Neovascularization, Pathologic) : Immunoprecipitation of RNA-protein complexes and luciferase reporter assays indicate that HuR antagonizes the suppressive activity of miR-200b, down-regulates miR-200b expression, and promotes VEGF-A expression