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HDAC8 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wilkinson et al., Mol Cell Biol 2005
:
p53 promotes SnoN and
histone deacetylase interaction at an overlapping Smad binding, p53 regulatory element ( SBE/p53RE ) in AFP
Blagosklonny et al., Cancer Res 2005
:
We suggest that, by either restoring or mimicking p53 trans-functions,
histone deacetylase inhibitors
initiate degradation of mutant
p53
Chang et al., J Virol 2008
:
Critical
role of
p53 in
histone deacetylase inhibitor induced Epstein-Barr virus Zta expression
Chen et al., EMBO J 2010
:
MDM2 also
inhibits p53 transcriptional activity by recruiting
histone deacetylase and corepressors to p53
Yan et al., Oncogene 2013
:
Importantly, we found that upon knockdown of each class I HDAC, only
HDAC8 knockdown
leads to decreased expression of wild-type and mutant
p53 proteins and transcripts ... Conversely, we found that ectopic expression of wild-type, but not mutant
HDAC8 ,
leads to increased transcription of
p53 ... Because of the fact that
HDAC8 is
required for expression of both wild-type and mutant
p53 , we found that targeted disruption of HDAC8 expression remarkably triggers proliferative defect in cells with a mutant, but not wild-type, p53