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SIVA1 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Du et al., Cell Death Differ 2009
(Bone Neoplasms) :
Here, we show that the
p53-Hdm2 interaction in unstressed cells is
promoted by
Siva1 , which, like Hdm2, is the product of a p53 target gene ...
Siva1 binds to both p53 and Hdm2 through distinct regions and
enhances Hdm2 mediated
p53 ubiquitination and degradation
Bhattacharya et al., Invest Ophthalmol Vis Sci 2011
:
Activation of
p53 in response to Nutlin-3 also
increased levels of Noxa, p53 upregulated modulator of apoptosis ( PUMA ), and
Siva-1 , decreased expression of Bcl-2 and Bcl-xL, and simultaneously increased caspases-9 and -3 activities and DNA fragmentation
Wang et al., Nature communications 2013
:
Functionally,
Siva1 regulates cell cycle progression and cell proliferation in an
ARF/p53 dependent manner