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CDK2 — HMGCR

Text-mined interactions from Literome

Saito et al., Thyroid 2001 : Thyrotropin ( TSH ) -initiated cell cycle progression from G1 to S phase in FRTL-5 thyroid cells requires serum, insulin, or insulin-like growth factor 1 (IGF-1) and involves activation of 3-hydroxy-3-methylglutaryl-CoA reductase , geranylgeranylation of RhoA, p27Kip1 degradation, and activation of cyclin dependent kinase (cdk) 2
Tanaka et al., J Biol Chem 1998 : Moreover, an inhibitor of HMG-CoA reductase , pravastatin, reduced cyclin E expression and Cdk2 activation and caused G1 arrest in the astrocytes