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JAK1 — MYC
Text-mined interactions from Literome
Konforte et al., J Immunol 2006
:
Our study is the first to show the link between IL-21 induced
JAK/STAT signaling,
c-Myc regulation , and differentiation of human B cells
Lee et al., J Cell Biochem 2009
:
JAK pathway
induction of
c-Myc critical to IL-5 stimulation of cell proliferation and inhibition of apoptosis ... We further examined the
role of
JAK1 and JAK2 in the induction of
c-Myc expression using the CDJAK fusion proteins, which consisted of a CD16 extracellular domain, a CD7 transmembrane domain, and either JAK1 ( CDJAK1 ) or JAK2 ( CDJAK2 ) as intracellular domains ... Simultaneous activation of
JAK1 and JAK2 by anti-CD16 antibody crosslinking of CDJAK1 and CDJAK2 could
induced c-Myc expression and promoter activity ; AG490 inhibited CDJAK1 and CDJAK2 mediated effects
Li et al., PloS one 2012
(Hypereosinophilic Syndrome) :
Interestingly,
JAK2 inhibition also reduced PI3K, Akt and NF-?B activity in a dose dependent manner, and
suppressed expression levels of
c-Myc and Survivin