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EPHB2 — SMAD6

Text-mined interactions from Literome

Leask et al., J Biol Chem 2003 : Now we show that protein kinase C and Ras/MEK/ERK are necessary for the TGF-beta induction of the CTGF promoter but not of a generic Smad-responsive promoter ( SBE-lux )
Kfir et al., Mol Cell Biol 2005 : Pathway- and expression level dependent effects of oncogenic N-Ras : p27 ( Kip1 ) mislocalization by the Ral-GEF pathway and Erk mediated interference with Smad signaling
Wang et al., Circ Res 2006 (Arteriosclerosis...) : This was extracellular signal regulated kinase 1/2 ( ERK1/2 ) mitogen activated protein kinase ( MAPK ) dependent but transforming growth factor-beta ( TGF-beta ) independent because Ang II-induced Smad signaling was blocked by addition of ERK1/2 inhibitor and by dominant negative ( DN ) ERK1/2 but not by DN-TGF-beta receptor II (TbetaRII) or conditional deletion of TbetaRII
Zhou et al., J Allergy Clin Immunol 2007 (Asthma...) : These increases occur as TGF-beta1 downregulates IL-13 induced phosphoinositide-3 kinase activation while leaving the positive effect of IL-13 induced ERK on Smad signaling
Zhou et al., Cardiovasc Res 2007 : On the other hand, stimulation of Smad 6 inhibits ERK activation and thus results in a negative feedback loop to fine-tune BMP signaling in HUVECs
Heger et al., J Cell Physiol 2010 (Cardiomegaly...) : Specific inhibitors of PI3K ( 10 microM LY290042 or 10 nM wortmannin ) or ERK ( 10 microM PD98059 ) also blocked GDF15 induced hypertrophy and SMAD activation
Hayashi et al., Clin Exp Nephrol 2012 : Stretch mediated down-regulation of Smad6 is partially involved in ERK1/2 activation