Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
SHC1
→
Complex of ITGAV-ITGB3
(increases, ITGAV/ITGB3 Activity, SHC1 Activity)
Giancotti et al., Science 1999 Evidence: The a5b1 integrin, which binds to fibronectin, induces expression of the antiapoptotic protein Bcl-2, protecting cells from apoptosis from stresses such as the lack of growth factors (55). Other integrins, including another fibronectin receptor, avb1, do not provide this survival effect. The avb3 integrin promotes endothelial and melanoma cell survival; this effect correlates with suppression of the p53 pathway and activation of the nuclear factor kappa B transcription factor (56). The activatio...