Gene interactions and pathways from curated databases and text-mining

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HMGB1 — RELA

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Pullerits et al., Arthritis Rheum 2003 (Arthritis, Experimental...) : In addition, spleen cells were cultured in the presence of HMGB-1 , and nuclear factor kappaB (NF-kappaB) activation was detected by electrophoretic mobility shift assay
Park et al., J Biol Chem 2004 : Transfections with dominant negative constructs demonstrated that TLR 2 and TLR 4 were both involved in HMGB1 induced activation of NF-kappaB
Dumitriu et al., J Immunol 2005 : HMGB1/RAGE interaction results in downstream activation of MAPKs and NF-kappaB
Völp et al., Gut 2006 (Colonic Neoplasms) : HMGB1 increased NFkappaB activity and led to co-overexpression of the antiapoptotic NFkappaB target gene product c-IAP2 in vitro
Maeda et al., Biochem Biophys Res Commun 2007 (Colitis...) : In macrophages, HMGB1 induces several proinflammatory cytokines, such as IL-6, which are regulated by NF-kappaB activation ... In macrophages, HMGB1 induces several proinflammatory cytokines, such as IL-6, which are regulated by NF-kappaB activation
van Beijnum et al., Angiogenesis 2008 (Neovascularization, Pathologic) : Furthermore, HMGB1 induced signaling can activate NFkappaB , which can subsequently induce the expression of HMGB1 receptors
Lv et al., Thromb Haemost 2009 : Moreover, HMGB1 increased expression of Egr-1 and nuclear translocation of NF-kappaB ( c-Rel/p65 ) in ECs ... Moreover, HMGB1 increased expression of Egr-1 and nuclear translocation of NF-kappaB ( c-Rel/p65 ) in ECs ... Taken together, our data suggest that HMGB1 induces TF expression in vascular endothelial cells via cell surface receptors ( TLR4, TLR2, and RAGE ), and through activation of transcription factors ( NF-kappaB and Egr-1 )
Feng et al., Int Immunopharmacol 2013 (Diabetes Mellitus...) : Immunofluorescence and Western blotting assays showed that CM1 could attenuate HMGB1 induced intracellular ERK1/2 and NF-kB activation in HUVECs